Journal Mobile Options
Table of Contents
Vol. 69, No. 2, 1982
Issue release date: 1982
Int Arch Allergy Immunol 1982;69:113–119
(DOI:10.1159/000233157)
Original Paper

L-Tyrosine as an Immunological Adjuvant

Wheeler A.W. · Moran D.M. · Robins B.E. · Driscoll A.
Beecham Pharmaceuticals Research Division, Great Burgh, Epsom, Surrey, England

Abstract

A series of experiments has been carried out to investigate the adjuvant properties of the amino acid L-tyrosine in laboratory animals. Adsorption of various allergenic materials to L-tyrosine was found to enhance the induction of IgG antibodies, but no unusual propensity to stimulate IgE antibody or delayed hypersensitivity was observed. Administration of the amino acid at a site remote from the allergen was found not to augment antibody production. This, together with evidence of reduced bioavailability of the tyrosine-adsorbed allergen, suggested that the adjuvant activity observed resulted from a short-term depot effect.

 goto top of outline Author Contacts

Correspondence to: Dr. A. W. Wheeler, Beecham Pharmaceuticals, Biosciences Research Centre, Yew Tree Bottom Road, Epsom, Surrey, KT 18, 5XQ (England)


 goto top of outline Article Information

Received: October 28, 1981
Published online: July 31, 2009
Number of Print Pages : 7


 goto top of outline Publication Details

International Archives of Allergy and Immunology

Vol. 69, No. 2, Year 1982 (Cover Date: 1982)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.