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Table of Contents
Vol. 69, No. 3, 1982
Issue release date: 1982
Section title: Short Communication
Int Arch Allergy Immunol 1982;69:282–284
(DOI:10.1159/000233185)

Subthreshold and Suboptimal Desensitization of Human Basophils

II. Nonspecificity and Irreversibility of Desensitization

Mendoza G.R. · Minagawa K.
Division of Immunology/Allergy, Department of Pediatrics, UCLA Center for the Health Sciences, and UCLA Center for Interdisciplinary Research in Immunologic Diseases, Los Angeles, Calif., USA

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Published online: July 31, 2009
Issue release date: 1982

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Desensitization in human basophils was induced by suboptimal levels of antihuman IgE or antigen under normal calcium buffer conditions. Low doses of anti-IgE triggered only 0–12% histamine release during a 3-hour preincubation, yet initiated up to 100% desensitization upon rechallenge. After 24–27 h preincubation with allergena, the cells did not regain releasability when rechallenged with either allergena, allergenb or anti-IgE. Low dose, IgE-mediated desensitization in human basophils may lead to an irreversible and nonspecific inhibition of degranulation.

© 1982 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Published online: July 31, 2009
Issue release date: 1982

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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