Interactions between Mast Cells, Fibroblasts and Connective Tissue ComponentsAtkins F.M. · Friedman M.M. · Subba Rao P.V. · Metcalfe D.D.
Division of Molecular Virology and Immunology, Georgetown University Medical Center, Rockville, Md., USA; Indian Institute of Science, Bangalore, India; Allergic Diseases Section, Laboratory of Clinical Investigation, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Md., USA
It has long been recognized that mast cells occur throughout connective tissues. Histologic studies have revealed that such cells release their granules into the surrounding environment upon exposure to both immunologic and nonimmunologic stimuli. By microscopy these extracellular granules appeared to be phagocytosed by fibroblasts and by blood-borne phagocytic cells as they entered the site of mast cell degranulation. Such in vivo observations led to the suggestion that mast cells both altered connective tissue components and influenced fibroblast function through these discharged granules. Recent in vitro studies using cultured fibroblasts and isolated mast cells and mast cell granules have confirmed both these hypotheses. In addition, such studies have also documented that fibroblasts degrade ingested mast cell granules. Such studies document that a number of critical interactions may occur between mast cells and connective tissue components.
Correspondence to: Dr. Dean D. Metcalfe, National Institutes of Health, Building 10, Room 11C210, Bethesda, MD 20205 (USA)
Published online: August 04, 2009
Number of Print Pages : 7
International Archives of Allergy and Immunology
Vol. 77, No. 1-2, Year 1985 (Cover Date: 1985)
Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)
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