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Vol. 77, No. 1-2, 1985
Issue release date: 1985
Section title: Asthma; Clinical Allergy
Int Arch Allergy Immunol 1985;77:155–157

Naturally Occurring Flavonoids and Human Basophil Histamine Release

Middleton, Jr. E. · Drzewiecki G.
Allergy Division, Departments of Medicine and Pediatrics School of Medicine, State University of New York at Buffalo and the Buffalo General Hospital, Buffalo, N.Y., USA

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Naturally occurring plant flavonoids, normal dietary constituents, affect a variety of cell activation phenomena including the secretion of histamine from human basophils stimulated by a variety of agents (antigen, anti-IgE, concanavalin A, ionophore A23187, formyl-Met-Leu-Phe and tetradecanoyl phorbol acetate). Variable profiles of inhibition are seen depending on the nature of the stimulus and the chemical structure of flavonoids.


Author Contacts

Correspondence to: Dr. Elliott Middleton, Jr., Department of Medicine, State University of New York at Buffalo, Buffalo General Hospital, 100 High Street, Buffalo, NY 14203 (USA)


Article Information

Published online: August 04, 2009
Number of Print Pages : 3


Publication Details

International Archives of Allergy and Immunology

Vol. 77, No. 1-2, Year 1985 (Cover Date: 1985)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

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Article / Publication Details

First-Page Preview
Abstract of Asthma; Clinical Allergy

Published online: 8/4/2009

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information:

Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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