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Vol. 84, No. 2, 1987
Issue release date: 1987
Int Arch Allergy Immunol 1987;84:173–177
Original Paper

Humoral Immune Response to Cow’s Milk in Children with Cow’s Milk Allergy

Relationship to the Time of Clinical Response to Cow’s Milk Challenge

Firer M.A.a · Hoskings C.S.b · Hill D.J.c
aDepartment of Chemical Immunology, Weizmann Institute of Science, Rehovot, Israel; bDepartment of Immunology, and cAllergy-Clinical Immunology Unit, Royal Children’s Hospital, Parkville, Victoria, Australia


In 47 infants and children aged 4–66 months with clinically proven cow’s milk allergy and in a group of age-matched controls, serum IgG, IgA and IgM cow’s milk-specific antibodies were determined with ELISA assays while IgE cow’s milk-specific antibodies were measured with Pharmacia RAST. The patients were divided into three separate groups according to the time of clinical response to a standardized cow’s milk challenge protocol. Immediate reactions ( < 45 min after challenge), which were mainly accompanied by urticarial skin eruptions, were associated with elevated IgE milk-specific antibody levels, indicating the involvement of an immediate hypersensitivity mechanism. Alternatively, intermediate reactions (1–20 h after challenge), which were mainly accompanied by vomiting and diarrhea, were not IgE-mediated. In the late reactions ( > 20 h after challenge) both eczematous and gastrointestinal reactions were seen. Patients with eczema-tous eruptions also showed elevated IgE milk-specific antibody levels. IgG milk-specific antibody levels were similar in each of the patient groups but all groups were significantly lower than in the controls. Levels of IgA and IgM milk-specific antibodies were similar in patients and controls. The results indicate that different im-munopathogenic mechanisms are operative in these subgroups of patients with cow’s milk allergy.

 goto top of outline Author Contacts

Correspondence to: Dr. D.J. Hill, Allergy-Clinical Immunology Unit, Royal Children’s Hospital, Flemington Road, Parkville, Victoria 3052 (Australia)

 goto top of outline Article Information

Received: October 25, 1986
Published online: August 05, 2009
Number of Print Pages : 5

 goto top of outline Publication Details

International Archives of Allergy and Immunology

Vol. 84, No. 2, Year 1987 (Cover Date: 1987)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

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