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Vol. 88, No. 1-2, 1989
Issue release date: 1989
Section title: Cellular Network: Inflammatory and Allergic Reactions
Int Arch Allergy Immunol 1989;88:212–215
(DOI:10.1159/000234789)

Inhibition of Human Eosinophil Chemotaxis and of the IgE-Dependent Stimulation of Human Blood Platelets by Cetirizine

De Vos C. · Joseph M. · Leprevost C. · Vorng H. · Tomassini M. · Capron M. · Capron A.
Centre d’Immunologie et de Biologie Parasitaire, Unité mixte INSERM 167-CNRS 624-Institut Pasteur, Lille, France

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Article / Publication Details

First-Page Preview
Abstract of Cellular Network: Inflammatory and Allergic Reactions

Published online: 8/5/2009
Issue release date: 1989

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Cetirizine is a new anti-allergic compound with a potent, long-acting, and specific antihistaminic property. Strongly active in the therapy of urticaria and seasonal or perennial rhinitis, it has been shown to inhibit the in vivo eosinophil attraction at skin sites challenged with allergen in atopic patients. In the present work, we confirmed that, at a therapeutical concentration, this molecule had a potent inhibitory action in vitro on eosinophil chemotaxis induced either by N-formyl-Met-Leu-Phe or platelet-activating factor and also on the IgE-dependent stimulation of platelets. These observations appear in favour of a possible role for cetirizine in the modulation of inflammatory cell interactions in allergic processes.

© 1989 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Dr. Christine De Vos, UCB SA, Pharmaceutical Sector, Chemin du Foriest, B-1420 Braine-l’Alleud (Belgium)

  

Article Information

Published online: August 05, 2009
Number of Print Pages : 4

  

Publication Details

International Archives of Allergy and Immunology

Vol. 88, No. 1-2, Year 1989 (Cover Date: 1989)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Cellular Network: Inflammatory and Allergic Reactions

Published online: 8/5/2009
Issue release date: 1989

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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