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Table of Contents
Vol. 60, No. 1, 2009
Issue release date: September 2009
Section title: Special Topic Section: Epigenomics in Psychiatry Editor: T. Kinoshita Review
Editor's Choice -- Free Access
Neuropsychobiology 2009;60:5–11

Epigenetic Profiling in Schizophrenia and Major Mental Disorders

Iwamoto K. · Kato T.
Laboratory for Molecular Dynamics of Mental Disorders, RIKEN Brain Science Institute, Wako, Japan
email Corresponding Author

Kazuya Iwamoto

Laboratory for Molecular Dynamics of Mental Disorders

RIKEN Brain Science Institute

2-1 Hirosawa, Wako, Saitama 351-0198 (Japan)

Tel. +81 48 467 6949, Fax +81 48 467 6947, E-Mail kaziwamoto@brain.riken.jp

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Epigenetic alterations such as DNA methylation and histone modifications are important in the etiology or pathophysiology of mental disorders. Here, we review recent studies on the relationship between DNA methylation and major mental disorders. We will focus on the role of DNA methylation in postmitotic neurons, intra- and interindividual variations in DNA methylation, the possible involvement of methionine metabolism pathways, and candidate and genome-wide DNA methylation as they relate to mental disorders.

© 2009 S. Karger AG, Basel

Article / Publication Details

First-Page Preview
Abstract of Special Topic Section: Epigenomics in Psychiatry Editor: T. Kinoshita Review

Received: October 01, 2008
Accepted: December 22, 2008
Published online: August 14, 2009
Issue release date: September 2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0302-282X (Print)
eISSN: 1423-0224 (Online)

For additional information: http://www.karger.com/NPS

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