Presence of Felis domesticus Allergen I in the Cat’s Salivary and Lacrimal Glandsvan Milligen F.J.a · Vroom T.M.b · Aalberse R.C.a
aCentral Laboratory of The Netherlands Red Cross Blood Transfusion Service and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, and bDepartment of Pathology, Slotervaart Hospital, Amsterdam, The Netherlands
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Most of the IgE response in persons allergic to cats is directed against the cat allergen Fe1 d I (Felis domesticus allergen I). Although the presence of Fe1 d I in saliva has been demonstrated, the source of Fe1 d I is not completely known. We measured Fe1 d I concentrations in the cat’s lacrimal and salivary glands and in the excretes lacrimal fluid, milk and saliva. The concentration of Fe1 d I, determined by a radioimmunoassay, in the lacrimal gland was 390–780 mU/g tissue and in the sublingual gland 610 mU/g tissue. In the parotid gland and especially the submandibular gland only low concentrations were found, respectively 70–210 and 40–50 mU/g tissue. In lacrimal fluid 6.8–14 U/ml Fe1 d l was detected, which is comparable to saliva, 4.2–7.0 U/ml, whereas in cat’s milk only 0.33 U/ml Fel d I was found. Immunohistochemical studies with monoclonal antibody directed against Fe1 d I (anti-Fe1 d I) showed the presence of Fe1 d I in the serous cells of the lacrimal gland. Thus, our results demonstrate that in particular the lacrimal gland might be a useful Fe1 d I source.
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