Most of the IgE response in persons allergic to cats is directed against the cat allergen Fe1 d I (
allergen I). Although the presence of Fe1 d I in saliva has been demonstrated, the source of Fe1 d I is not completely known. We measured Fe1 d I concentrations in the cat’s lacrimal and salivary glands and in the excretes lacrimal fluid, milk and saliva. The concentration of Fe1 d I, determined by a radioimmunoassay, in the lacrimal gland was 390–780 mU/g tissue and in the sublingual gland 610 mU/g tissue. In the parotid gland and especially the submandibular gland only low concentrations were found, respectively 70–210 and 40–50 mU/g tissue. In lacrimal fluid 6.8–14 U/ml Fe1 d l was detected, which is comparable to saliva, 4.2–7.0 U/ml, whereas in cat’s milk only 0.33 U/ml Fel d I was found. Immunohistochemical studies with monoclonal antibody directed against Fe1 d I (anti-Fe1 d I) showed the presence of Fe1 d I in the serous cells of the lacrimal gland. Thus, our results demonstrate that in particular the lacrimal gland might be a useful Fe1 d I source.
Correspondence to: Dr. Florine van Milligen, c/o Publication Secretariat, Central Laboratory of The Netherlands Red Cross, Blood Transfusion Service, PO Box 9406, NL–1006 AK Amsterdam (The Netherlands)
Received: July 23, 1990
Accepted: August 18, 1990
Published online: August 07, 2009
Number of Print Pages : 4
International Archives of Allergy and Immunology
Vol. 92, No. 4, Year 1990 (Cover Date: 1990)
Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA
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