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Vol. 92, No. 1, 1990
Issue release date: 1990
Int Arch Allergy Immunol 1990;92:9–15
Original Paper

Serum Antibodies Reactive with Saccharomyces cerevisiae in Inflammatory Bowel Disease: Is IgA Antibody a Marker for Crohn’s Disease?

Barnes R.M.R.a · Allan S.a · Taylor-Robinson C.H.b · Finn R.a · Johnson P.M.a
Departments of aImmunology and bMedical Microbiology, University of Liverpool, UK


Sera from patients with Crohn’s disease (CD) and ulcerative colitis (UC) have been evaluated for antibodies reactive with Saccharomyces cerevisiae (anti-Sacc antibodies) using an enzyme-linked immunoassay (ELISA). IgG anti-Sacc antibodies were detected in 63% (25/40) of CD patients, compared with 15% (4/27) of UC patients (p <0.001) and 8% (5/60) healthy adult controls (p <0.001). Furthermore, the prevalence of detectable IgG anti-Sacc antibodies in adult patients with coeliac disease, dermatitis herpetiformis, irritable bowel syndrome or atopic eczema was not significantly different to controls. In comparison, the prevalence of detectable IgG anti-Escherichia coli antibodies was not significantly different between CD (75%) or UC (79%) patients. More particularly, elevated levels of serum IgA anti-Sacc antibodies were detected in 17/40 CD patients, but in none of the 27 UC patients. These data confirm that serum antibodies reactive with S. cerevisiae are strongly associated with CD and further show that serum IgA anti-Sacc antibodies may be specific for this disorder.

 goto top of outline Author Contacts

Correspondence to: Dr. R.M.R. Barnes, University Department of Immunology, Royal Liverpool Hospital, PO Box 147, Liverpool, L69 3BX (UK)

 goto top of outline Article Information

Received: October 12, 1989
Accepted after revision: February 20, 1990
Published online: August 07, 2009
Number of Print Pages : 7

 goto top of outline Publication Details

International Archives of Allergy and Immunology

Vol. 92, No. 1, Year 1990 (Cover Date: 1990)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

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