Sera from patients with Crohn’s disease (CD) and ulcerative colitis (UC) have been evaluated for antibodies reactive with Saccharomyces cerevisiae
(anti-Sacc antibodies) using an enzyme-linked immunoassay (ELISA). IgG anti-Sacc antibodies were detected in 63% (25/40) of CD patients, compared with 15% (4/27) of UC patients (p <0.001) and 8% (5/60) healthy adult controls (p <0.001). Furthermore, the prevalence of detectable IgG anti-Sacc antibodies in adult patients with coeliac disease, dermatitis herpetiformis, irritable bowel syndrome or atopic eczema was not significantly different to controls. In comparison, the prevalence of detectable IgG anti-Escherichia coli
antibodies was not significantly different between CD (75%) or UC (79%) patients. More particularly, elevated levels of serum IgA anti-Sacc antibodies were detected in 17/40 CD patients, but in none of the 27 UC patients. These data confirm that serum antibodies reactive with S. cerevisiae
are strongly associated with CD and further show that serum IgA anti-Sacc antibodies may be specific for this disorder.
Correspondence to: Dr. R.M.R. Barnes, University Department of Immunology, Royal Liverpool Hospital, PO Box 147, Liverpool, L69 3BX (UK)
Received: October 12, 1989
Accepted after revision: February 20, 1990
Published online: August 07, 2009
Number of Print Pages : 7
International Archives of Allergy and Immunology
Vol. 92, No. 1, Year 1990 (Cover Date: 1990)
Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA
Copyright / Drug Dosage
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