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Mechanisms of Inflammation in Allergic Disease and Its Pharmacological Modulation

Platelet-Activating Factor-Induced Immediate and Late Cutaneous Reactions

Rihoux J.-P.a · Fadel R.b · Juhlin L.c

Author affiliations

aUCB SA, Belgium; bInstitut Pasteur, Paris, France; cUniversity Hospital, Uppsala, Sweden

Corresponding Author

Correspondence to: Dr. L. Juhlin, Department of Dermatology, University Hospital, S–75185 Uppsala (Sweden)

Related Articles for ""

Int Arch Allergy Immunol 1991;94:299–300

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Abstract

In atopic subjects, intradermal injection of platelet-activating factor (PAF), 40 and 400 ng, resulted in an immediate edema reaction markedly blocked by cetirizine, 10 mg twice a day. PAF challenge also induced a significant eosinophil accumulation evidenced by a skin window technique at 2, 4, 8 and 24 h. This inflammatory phenomenon was significantly inhibited by cetirizine. In patients with chronic urticaria, PAF, 100 μg intradermally, induced immediate and late cutaneous reactions (LCR) also blocked by cetirizine, 10 mg twice a day. These LCR were accompanied by an infiltration of the deep dermis by degranulated eosinophils. The pathophysiological mechanism of the PAF-induced skin reactions is discussed as well as the mechanism of action of cetirizine.

© 1991 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Mechanisms of Inflammation in Allergic Disease and Its Pharmacological Modulation

Published online: August 07, 2009
Issue release date: 1991

Number of Print Pages: 2
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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