Influence of Bathing or Washing on Skin Barrier Function in Newborns during the First Four Weeks of LifeGarcia Bartels N. · Mleczko A. · Schink T. · Proquitté H. · Wauer R.R. · Blume-Peytavi U.
aDepartment of Dermatology and Allergy, Clinical Research Center for Hair and Skin Science, bDepartment of Medical Statistics and Clinical Epidemiology, and cClinic for Neonatology CCM, Charité-Universitätsmedizin Berlin, Berlin, Germany
Background and Objectives: After birth, skin barrier function is in state of flux and at risk of dysfunction. In a prospective clinical study, we compared the effects of 2 standard cleansing procedures on skin barrier function in newborns. Methods: Fifty-seven healthy full-term neonates aged ≤48 h were randomly assigned to either a bathing group (group B; n = 29), who were bathed with clear water twice weekly, or to a washing group (group W; n = 28), who were washed with a washcloth moistened with clear water twice weekly. Transepidermal water loss (TEWL), skin pH, stratum corneum hydration (SCH) and sebum production were measured at days 2, 7 and 28 of life on the forehead, abdomen, upper leg and buttock. Results: Group B showed significantly lower TEWL on the buttock and higher SCH on the abdomen and forehead compared to group W at day 28. Conclusions: Both skin care regimens do not harm the adaptation of the skin barrier in healthy neonates within the first 4 weeks of life. Skin barrier function differentiates after birth in a regionally specific fashion.
Dr. med. N. Garcia Bartels, Clinical Research Center for Hair and Skin Science
Department of Dermatology and Allergy, Charité-Universitätsmedizin Berlin
Charitéplatz 1, DE–10117 Berlin (Germany)
Tel. +49 30 450 518 259, Fax +49 30 450 518 952
N.G.B. and A.M. contributed equally to the paper. U.B.-P. is a consultant for Johnson & Johnson GmbH.
Received: January 27, 2009
Accepted after revision: May 19, 2009
Published online: August 18, 2009
Number of Print Pages : 10
Number of Figures : 6, Number of Tables : 2, Number of References : 29
Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)
Vol. 22, No. 5, Year 2009 (Cover Date: October 2009)
Journal Editor: Lademann J. (Berlin)
ISSN: 1660-5527 (Print), eISSN: 1660-5535 (Online)
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