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Microbial Pathogenomics

Editor(s): de Reuse H. (Paris) 
Bereswill S. (Berlin) 
Table of Contents
Vol. 6, No. , 2009
Section title: Paper
de Reuse H, Bereswill S (eds): Microbial Pathogenomics. Genome Dyn. Basel, Karger, 2009, vol 6, pp 170–186
(DOI:10.1159/000235770)

Legionella pneumophila – Host Interactions: Insights Gained from Comparative Genomics and Cell Biology

Lomma M. · Gomez Valero L. · Rusniok C. · Buchrieser C.
Institut Pasteur, Unité Biologie des Bactéries Intracellulaires and CNRS URA 2171, Paris, France

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Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/19/2009
Cover Date: 2009

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9192-8 (Print)
eISBN: 978-3-8055-9193-5 (Online)

Abstract

Legionella pneumophila is the etiological agent of Legionnaires’ disease and of the less acute disease Pontiac fever. It is a Gram-negative bacterium present in fresh and artificial water environments that replicates in protozoan hosts and is also found in biofilms. Replication within protozoa is essential for the survival of the bacterium. The last years have seen a giant step forward in the genomics of L. pneumophila. The establishment and publication of the complete genome sequences of three clinical L. pneumophila isolates in 2004 and a fourth in 2007 has paved the way for major breakthroughs in understanding the biology of L. pneumophila in particular and Legionella in general. Sequence analysis identified several specific features of Legionella: (i) an extraordinary genetic diversity among the different isolates and (ii) the presence of an unexpected high number and variety of eukaryotic-like proteins, predicted to be involved in the exploitation of the host cellular processes by mimicking specific eukaryotic functions. In this chapter, we will first discuss the insights gained from genomics by highlighting the characteristic features and common traits of the four L. pneumophila genomes obtained through genome analysis and comparison and then we will focus on the newest results obtained by functional analysis of different eukaryotic-like proteins and describe their involvementin the pathogenicity of L. pneumophila.


  

Author Contacts

Carmen Buchrieser, Biologie des Bactéries Intracellulaires, Institut Pasteur, 25, rue du Dr. Roux, FR-75724 Paris Cedex 15 (France), Tel. +33 1 45 68 83 72, Fax +33 1 45 68 87 86, E-Mail cbuch@pasteur.fr

  

Article Information

Number of Print Pages : 17

  

Publication Details

Book Serie: Genome Dynamics, Vol. 6, Year 2009

Editor(s): Volff, J.-N. (Lyon)
ISSN: 1660-9263 (Print), eISSN: 1662-3797 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1660-9263

Book Title: Microbial Pathogenomics

Editor(s): de Reuse H, Bereswill S (eds)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1660-9263&volume=6


Article / Publication Details

First-Page Preview
Abstract of Paper

Published online: 8/19/2009
Cover Date: 2009

Number of Print Pages: 17
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9192-8 (Print)
eISBN: 978-3-8055-9193-5 (Online)


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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