Cover

Microbial Host-Interaction: Tolerance versus Allergy

64th Nestlé Nutrition Institute Workshop, Pediatric Program, Sydney, November 2008

Editor(s): Brandtzaeg P. (Oslo) 
Isolauri E. (Turku) 
Prescott S.L. (Perth, W.A.) 
Table of Contents
Vol. 64, No. , 2009
Section title: Development of Normal Tolerance
Brandtzaeg P, Isolauri E, Prescott SL (eds): Microbial–Host Interaction: Tolerance versus Allergy. Nestlé Nutr Inst Workshop Ser Pediatr Program, vol 64, pp 23–43, Nestec Ltd., Vevey/S. Karger AG, Basel, © 2009
(DOI:10.1159/000235781)

‘ABC’ of Mucosal Immunology

Brandtzaeg P.
Laboratory for Immunohistochemistry and Immunopathology, Institute and Division of Pathology, University of Oslo, Rikshospitalet University Hospital, Oslo, Norway

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Complete book

  • Immediate access to all parts of this book
  • Cover-to-cover formats may be available
  • Unlimited re-access via MyKarger
  • Unrestricted printing, no saving restriction for personal use
read more

Pricing depends on hard-cover price


Select


Article / Publication Details

First-Page Preview
Abstract of Development of Normal Tolerance

Published online: 8/19/2009
Cover Date: 2009

Number of Print Pages: 21
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9167-6 (Print)
eISBN: 978-3-8055-9168-3 (Online)

Abstract

Two adaptive homeostatic mechanisms normally preserve mucosal integrity: (i) immune exclusion mediated by secretory antibodies to inhibit penetration of potentially dangerous microorganisms and proteins, and (ii) immunosuppression to counteract hypersensitivity against innocuous antigens. The latter mechanism is called ‘oral tolerance’ when induced via the gut. Similar mechanisms are suppressive against commensal bacteria. Such two-layered anti-inflammatory defense explains why persistent allergy to dietary proteins is not more common, with the exception of gluten intolerance (celiac disease) where abrogation of mucosal homeostasis is overt. Thus, mucosally induced tolerance is generally a robust adaptive mechanism in view of the fact that a ton of food may pass annually through the gut of an adult – regularly giving rise to uptake of intact dietary antigens in the nanogram range after a meal. However, the immunoregulatory network and the epithelial barrier are poorly developed in the neonatal period, which therefore is critical with regard to priming for allergy. Notably, the postnatal development of mucosal immune homeostasis depends on appropriate microbial colonization. In this process, antigen-presenting cells are ‘decision makers’, linking innate and adaptive immunity. Their microbe-sensing function is influenced by both microbial products and dietary constituents, including vitamin A and lipids such as polyunsaturated n-3 fatty acids.


  

Article Information

Number of Print Pages : 21

  

Publication Details

Book Serie: Nestlé Nutrition Institute Workshop Series: Pediatric Program, Vol. 64, Year 2009 ISSN: 1661-6677 (Print), eISSN: 1662-3878 (Online)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1661-6677

Book Title: Microbial Host-Interaction: Tolerance versus Allergy (64th Nestlé Nutrition Institute Workshop, Pediatric Program, Sydney, November 2008)

Editor(s): de Reuse H, Bereswill S (eds)

For additional information:
http://content.karger.com/ProdukteDB/produkte.asp?issn=1661-6677&volume=64


Article / Publication Details

First-Page Preview
Abstract of Development of Normal Tolerance

Published online: 8/19/2009
Cover Date: 2009

Number of Print Pages: 21
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9167-6 (Print)
eISBN: 978-3-8055-9168-3 (Online)


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.