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Cover

Microbial Host-Interaction: Tolerance versus Allergy

64th Nestlé Nutrition Institute Workshop, Pediatric Program, Sydney, November 2008

Editor(s): Brandtzaeg P. (Oslo) 
Isolauri E. (Turku) 
Prescott S.L. (Perth, W.A.) 
Table of Contents
Vol. 64, No. , 2009
Section title: Nutrition and Immunological Homeostasis
Brandtzaeg P, Isolauri E, Prescott SL (eds): Microbial–Host Interaction: Tolerance versus Allergy. Nestlé Nutr Inst Workshop Ser Pediatr Program, vol 64, pp 219–238, Nestec Ltd., Vevey/S. Karger AG, Basel, © 2009
(DOI:10.1159/000235793)

Probiotics and Prebiotics: Immunological and Clinical Effects in Allergic Disease

Tang M.L.K.
Department of Allergy and Immunology, Royal Children’s Hospital, Parkville, Vic., Australia

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Article / Publication Details

First-Page Preview
Abstract of Nutrition and Immunological Homeostasis

Published online: August 19, 2009
Cover Date: 2009

Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9167-6 (Print)
eISBN: 978-3-8055-9168-3 (Online)

Abstract

The intestinal microbiota plays an important role in immune development and may play a role in the development of allergic disorders. Manipulation of the intestinal microbiota may therefore offer an approach to the prevention or treatment of allergic diseases. Probiotics and prebiotics, used alone or together (synbiotics), can influence the intestinal microbiota and modulate immune responses in vitro and in vivo. Clinical studies suggest a potential role for selected probiotics (alone or in combination with prebiotics) in the prevention of atopic eczema. A prenatal component of treatment appears important for beneficial effects. Effects are dependent upon the specific bacteria and characteristics of the study population. One study reported beneficial effects for prebiotics in the prevention of eczema in high-risk infants, however, further studies are required to confirm this. The use of probiotics in the treatment of allergic disease is less promising. A Cochrane meta-analysis concluded that probiotics are not effective for the treatment of atopic dermatitis. Probiotic effects in the treatment of asthma and allergic rhinitis are conflicting. Probiotics, prebiotics and synbiotics offer potential treatments for the prevention of atopic eczema; however, there is currently insufficient evidence to recommend their use in clinical practice. Studies to clarify the optimal dose, bacterial species/strains, whether there is added benefit with synbiotics, the optimal timing for intervention, and the patient populations who would benefit most from such therapies are warranted.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Nutrition and Immunological Homeostasis

Published online: August 19, 2009
Cover Date: 2009

Number of Print Pages: 20
Number of Figures: 0
Number of Tables: 0

ISBN: 978-3-8055-9167-6 (Print)
eISBN: 978-3-8055-9168-3 (Online)


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Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in government regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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