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Vol. 224, No. 3, 2010
Issue release date: April 2010
Section title: Original Paper
Ophthalmologica 2010;224:138–146
(DOI:10.1159/000236039)

Efficacy and Tolerability of Nonpenetrating Filtering Surgery in the Treatment of Open-Angle Glaucoma: A Meta-Analysis

Cheng J.-W. · Xi G.-L. · Wei R.-L. · Cai J.-P. · Li Y.
aDepartment of Ophthalmology, Changzheng Hospital, and bCenter for New Drug Evaluation, Second Military Medical University, Shanghai, China

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/8/2007
Accepted: 4/24/2008
Published online: 9/9/2009

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 5

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH

Abstract

Aims:To evaluate the efficacy and tolerability of nonpenetrating filtering surgery in the treatment of patients with open-angle glaucoma. Methods: Pertinent studies were selected by extensive searches. A total of 17 randomized controlled trials were included in the present meta-analysis. The main outcome measures were risk differences (RDs) of complete success for efficacy and postoperative complications for tolerability. Pooled estimates were computed according to a random-effects model. Results:Viscocanalostomy and deep sclerectomy were significantly less effective than tra- beculectomy, and pooled RDs of complete success were –0.16 (95% confidence interval, CI, –0.30 to –0.02) and –0.10 (–0.19 to 0.00). Deep sclerectomy plus mitomycin C (MMC) was also less effective than trabeculectomy plus MMC, with pooled RD of complete success being –0.16 (95% CI –0.32 to –0.01). Viscocanalostomy and deep sclerectomy caused main complications in fewer patients than trabeculectomy. Conclusions:Viscocanalostomy and deep sclerectomy were less effective than trabeculectomy in the treatment of open-angle glaucoma, and deep sclerectomy plus MMC was also less effective than trabeculectomy plus MMC. However, viscocanalostomy and deep sclerectomy were associated with fewer complications than trabeculectomy.


  

Author Contacts

Rui-Li Wei
Department of Ophthalmology, Changzheng Hospital
Second Military Medical University, 415 Fengyang Road
Shanghai 200003 (China)
Tel. +86 21 8188 5921, Fax +86 21 6351 9814, E-Mail ruiliwei@gmail.com

  

Article Information

Jin-Wei Cheng and Gui-Lin Xi contributed equally to this work.

Received: November 8, 2007
Accepted after revision: April 24, 2008
Published online: September 9, 2009
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 5, Number of References : 41

  

Publication Details

Ophthalmologica (International Journal of Ophthalmology)

Vol. 224, No. 3, Year 2010 (Cover Date: April 2010)

Journal Editor: Ohrloff C. (Frankfurt a.M.), Cunha-Vaz J. (Coimbra)
ISSN: 0030-3755 (Print), eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 11/8/2007
Accepted: 4/24/2008
Published online: 9/9/2009

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 5

ISSN: 0030-3755 (Print)
eISSN: 1423-0267 (Online)

For additional information: http://www.karger.com/OPH


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