Efficacy and Tolerability of Nonpenetrating Filtering Surgery in the Treatment of Open-Angle Glaucoma: A Meta-AnalysisCheng J.-W. · Xi G.-L. · Wei R.-L. · Cai J.-P. · Li Y.
aDepartment of Ophthalmology, Changzheng Hospital, and bCenter for New Drug Evaluation, Second Military Medical University, Shanghai, China
Aims:To evaluate the efficacy and tolerability of nonpenetrating filtering surgery in the treatment of patients with open-angle glaucoma. Methods: Pertinent studies were selected by extensive searches. A total of 17 randomized controlled trials were included in the present meta-analysis. The main outcome measures were risk differences (RDs) of complete success for efficacy and postoperative complications for tolerability. Pooled estimates were computed according to a random-effects model. Results:Viscocanalostomy and deep sclerectomy were significantly less effective than tra- beculectomy, and pooled RDs of complete success were –0.16 (95% confidence interval, CI, –0.30 to –0.02) and –0.10 (–0.19 to 0.00). Deep sclerectomy plus mitomycin C (MMC) was also less effective than trabeculectomy plus MMC, with pooled RD of complete success being –0.16 (95% CI –0.32 to –0.01). Viscocanalostomy and deep sclerectomy caused main complications in fewer patients than trabeculectomy. Conclusions:Viscocanalostomy and deep sclerectomy were less effective than trabeculectomy in the treatment of open-angle glaucoma, and deep sclerectomy plus MMC was also less effective than trabeculectomy plus MMC. However, viscocanalostomy and deep sclerectomy were associated with fewer complications than trabeculectomy.
Department of Ophthalmology, Changzheng Hospital
Second Military Medical University, 415 Fengyang Road
Shanghai 200003 (China)
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Jin-Wei Cheng and Gui-Lin Xi contributed equally to this work.
Received: November 8, 2007
Accepted after revision: April 24, 2008
Published online: September 9, 2009
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 5, Number of References : 41
Ophthalmologica (International Journal of Ophthalmology)
Vol. 224, No. 3, Year 2010 (Cover Date: April 2010)
Journal Editor: Ohrloff C. (Frankfurt a.M.), Cunha-Vaz J. (Coimbra)
ISSN: 0030-3755 (Print), eISSN: 1423-0267 (Online)
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