Efficacy and Tolerability of Nonpenetrating Filtering Surgery in the Treatment of Open-Angle Glaucoma: A Meta-AnalysisCheng J.-W.a · Xi G.-L.b · Wei R.-L.a · Cai J.-P.a · Li Y.a
aDepartment of Ophthalmology, Changzheng Hospital, and bCenter for New Drug Evaluation, Second Military Medical University, Shanghai, China
Aims:To evaluate the efficacy and tolerability of nonpenetrating filtering surgery in the treatment of patients with open-angle glaucoma. Methods: Pertinent studies were selected by extensive searches. A total of 17 randomized controlled trials were included in the present meta-analysis. The main outcome measures were risk differences (RDs) of complete success for efficacy and postoperative complications for tolerability. Pooled estimates were computed according to a random-effects model. Results:Viscocanalostomy and deep sclerectomy were significantly less effective than tra- beculectomy, and pooled RDs of complete success were –0.16 (95% confidence interval, CI, –0.30 to –0.02) and –0.10 (–0.19 to 0.00). Deep sclerectomy plus mitomycin C (MMC) was also less effective than trabeculectomy plus MMC, with pooled RD of complete success being –0.16 (95% CI –0.32 to –0.01). Viscocanalostomy and deep sclerectomy caused main complications in fewer patients than trabeculectomy. Conclusions:Viscocanalostomy and deep sclerectomy were less effective than trabeculectomy in the treatment of open-angle glaucoma, and deep sclerectomy plus MMC was also less effective than trabeculectomy plus MMC. However, viscocanalostomy and deep sclerectomy were associated with fewer complications than trabeculectomy.
© 2009 S. Karger AG, Basel
Jin-Wei Cheng and Gui-Lin Xi contributed equally to this work.
Received: November 8, 2007
Accepted after revision: April 24, 2008
Published online: September 9, 2009
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 5, Number of References : 41
Ophthalmologica (International Journal of Ophthalmology)
Vol. 224, No. 3, Year 2010 (Cover Date: April 2010)
Journal Editor: Ohrloff C. (Frankfurt a.M.), Cunha-Vaz J. (Coimbra)
ISSN: 0030-3755 (Print), eISSN: 1423-0267 (Online)
For additional information: http://www.karger.com/OPH