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Vol. 77, No. 3-4, 2009
Issue release date: September 2009
Section title: Clinical Study
Oncology 2009;77:224–230
(DOI:10.1159/000236046)

The Role of KRAS Mutations in Predicting the Efficacy of Cetuximab-Plus-Irinotecan Therapy in Irinotecan-Refractory Korean Metastatic Colorectal Cancer Patients

Sohn B.S. · Kim T.W. · Lee J.-L. · Ryu M.-H. · Chang H.M. · Kang Y.-K. · Park H.S. · Na Y.-S. · Jang S.J. · Kim J.C. · Lee J.S.
Departments of aInternal Medicine, bOncology, cPathology and dColon and Rectal Surgery, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 1/22/2009
Accepted: 4/28/2009
Published online: 9/7/2009

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL

Abstract

Objective: This study evaluated the clinical relevance of KRAS and BRAF mutational status in 66 irinotecan-refrac- tory Korean metastatic colorectal cancer (mCRC) patients treated with cetuximab-plus-irinotecan-based chemotherapy. Methods: A total of 66 irinotecan-refractory mCRC patients treated with cetuximab-plus-irinotecan-based chemotherapy were included. Tumors were screened for KRAS mutations (codons 12 and 13) and a BRAF mutation (V600E) using direct sequencing and the Snapshot assay. Results: The objective response rate (RR) for treatment was 21.2% (14/66) and skin rashes were observed in 43 (65.2%) of the 66 patients. A KRAS mutation was detected in 27 (40.9%) tumors, and was associated with lower RR (wild-type vs. mutated KRAS: 33.3 vs. 3.7%, p = 0.005) and shorter progression-free survival (PFS) and overall survival (OS; PFS: 6.4 vs. 2.0 months, p = 0.005; OS: 17.8 vs. 7.1 months, p = 0.001). Severe skin toxicity was associated with better RR and longer PFS and OS. BRAF mutations were not detected. Multivariate analysis revealed that KRAS status and skin toxicity were independent predictive factors of PFS and OS. Conclusions: This study indicates the clinical relevance of KRAS mutations in predicting the efficacy of cetuximab-plus-irinotecan-based chemotherapy in irinotecan-refractory Korean mCRC patients.


  

Author Contacts

Tae Won Kim
Department of Oncology, Asan Medical Center
University of Ulsan College of Medicine
86 Asanbyeongwon-gil, Songpa-gu, Seoul 138-736 (Korea)
Tel. +82 2 3010 3910, Fax +82 2 3010 6961, E-Mail twkimmd@amc.seoul.kr

  

Article Information

Received: January 22, 2009
Accepted after revision: April 28, 2009
Published online: September 7, 2009
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 3, Number of References : 32

  

Publication Details

Oncology (International Journal of Cancer Research and Treatment)

Vol. 77, No. 3-4, Year 2009 (Cover Date: September 2009)

Journal Editor: Markman M. (Houston, Tex.)
ISSN: 0030-2414 (Print), eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 1/22/2009
Accepted: 4/28/2009
Published online: 9/7/2009

Number of Print Pages: 7
Number of Figures: 1
Number of Tables: 3

ISSN: 0030-2414 (Print)
eISSN: 1423-0232 (Online)

For additional information: http://www.karger.com/OCL


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