Arachidonic Acid Supplementation Decreases P300 Latency and Increases P300 Amplitude of Event-Related Potentials in Healthy Elderly MenIshikura Y. · Ikeda G. · Akimoto K. · Hata M. · Kusumoto A. · Kidokoro A. · Kontani M. · Kawashima H. · Kiso Y. · Koga Y.
aInstitute for Health Care Science, Suntory Ltd., Osaka, bDepartment of Global Agricultural Sciences, Graduate School of Agricultural and Life Sciences, University of Tokyo, and cDepartment of Neuropsychiatry, Kyorin University School of Medicine, Tokyo, Japan
In the present study, we examined the effects of arachidonic acid (ARA) on age-related event-related potential (ERP) changes in 25 healthy elderly men. This study was performed using a double-blind crossover design. The subjects were administered 600 mg/day of ARA-enriched triglyceride (SUNTGA40S; containing 240 mg ARA) in capsules or the same amount of olive oil in capsules as an inactive placebo for 1 month. ERPs were measured before capsule administration and after 1 month of administration, and P300 latency and amplitude were also measured. In subjects administered 240 mg/day ARA, P300 latency was significantly shorter, and P300 amplitude was significantly higher than in those administered olive oil capsules, and they exhibited a significant increase in ARA content in serum phospholipids. These findings suggest that supplementation of ARA can improve cognitive function in healthy elderly men.
Institute for Health Care Science, Suntory Ltd.
1-1-1 Wakayamadai, Shimamoto-cho, Mishima-gun
Osaka 618-8503 (Japan)
Tel. +81 75 962 8895, Fax +81 75 962 3792, E-Mail Yoshiyuki_Ishikura@suntory.co.jp
Conflict of Interest Statement: Several authors belong to Suntory Ltd. (see affiliation) that markets the health food product which includes arachidonic acid evaluated in this article.
Received: September 24, 2007
Accepted: June 4, 2009
Published online: September 10, 2009
Number of Print Pages : 7
Number of Figures : 1, Number of Tables : 4, Number of References : 24
Neuropsychobiology (International Journal of Experimental and Clinical Research in Biological Psychiatry, Pharmacopsychiatry, Biological Psychology/Pharmacopsychology and Pharmacoelectroencephalography)
Vol. 60, No. 2, Year 2009 (Cover Date: October 2009)
Journal Editor: Strik W. (Bern)
ISSN: 0302-282X (Print), eISSN: 1423-0224 (Online)
For additional information: http://www.karger.com/NPS