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Table of Contents
Vol. 103, No. 3, 1994
Issue release date: 1994
Section title: Original Paper
Int Arch Allergy Immunol 1994;103:274–279
(DOI:10.1159/000236639)

IgE and lgG4 Binding to Synthetic Peptides of the Cat (Felis domesticus) Major Allergen Fel d I

van Milligen F.J. · van’t Hof W. · Aalberse R.C.
Central Laboratory of the Netherlands Red Cross Blood Transfusion Service, and Laboratory for Experimental and Clinical Immunology, University of Amsterdam, The Netherlands

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 03, 2009
Issue release date: 1994

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Specificities of IgE and IgG4 antibodies in 12 cat-allergic patients were compared with respect to their reactivity towards 3 IgE-binding synthetic peptides of Felis domesticus allergen 1 (Fel d I): peptides 25–38 and 46–59 of chain 1 and peptide 15–28 of chain 2. Peptides were coupled to Sepharose and anti-Feld I antibodies were isolated by affinity chromatography. Fel d I-specific IgE- and IgG4 antibody activity in the peptide eluates was measured using Fel d I binding assays. Fel d I-specific IgE/IgG4 ratios in the eluates from peptide-Sepharose were determined and compared with the IgE/IgG4 ratios in the eluates from Fel d I-Sepharose. The mean ratio Fel d I-specific IgE/IgG4 in the peptide eluates (0.84; range 0.06–4.6) was significantly higher than the mean ratio in the eluates from Fel d I-Sepharose (0.31; range 0.13–1.1), demonstrating a higher reactiviy of IgE antibodies with the peptides, compared to IgG4. These results indicate differences between the B cells producing IgE antibodies and the B cells producing IgG4 antibodies.

© 1994 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: September 03, 2009
Issue release date: 1994

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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