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Vol. 106, No. 2, 1995
Issue release date: 1995
Section title: Original Paper
Int Arch Allergy Immunol 1995;106:134–138
(DOI:10.1159/000236833)

Antibody Response against Wheat, Rye, Barley, Oats and Corn: Comparison between Gluten-Sensitive Patients and Monoclonal Antigliadin Antibodies

Vainio E. · Varjonen E.
Departments of Dermatology and Medical Microbiology, Turku University, Turku, Finland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/30/1994
Accepted: 9/27/1994
Published online: 9/4/2009
Issue release date: 1995

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

The antibody response of patients with gluten-sensitive enteropathy and dermatitis herpetiformis against alcohol-soluble prolamines of wheat, rye, barley, oats and corn assessed by immunoblotting was compared to the staining patterns produced by monoclonal antigliadin antibodies. Both monoclonal antibodies (MAbs) and patient serum reacted with wheat, rye, barley and oats, the patient serum showing individual variation both in IgA and IgG stainings. A broad reactivity with polypeptides from 30 to 68 kD was, however, typical for patient serum and comparable to the reactivity of two broadly reacting antigliadin MAbs. This kind of broad reactivity of the MAb may suggest that it binds to glutamine-repeating sequences of highly homologous gliadin polypeptides. Glutamine- and proline-containing motifs Pro-Ser-Gln-Gln and Gln-Gln-Gln-Pro are also included in the peptides toxic to the celiac small intestinal mucosa. Our study indicates that the humoral response of the patients may detect similar structures, in oat prolamines as well. Patient serum and one of the MAbs also reacted with a 22-kD polypeptide of corn extract. The meaning of this reativity is not known, and further characterization of the antigenic epitopes of different cereals will be important.


  

Author Contacts

Correspondence to: Dr. Eeva Vainio, MD, Department of Dermatology, University of Turku, FIN–20520 Turku (Finland)

  

Article Information

Received: May 30, 1994
Accepted after revision: September 27, 1994
Published online: September 04, 2009
Number of Print Pages : 5

  

Publication Details

International Archives of Allergy and Immunology

Vol. 106, No. 2, Year 1995 (Cover Date: 1995)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/30/1994
Accepted: 9/27/1994
Published online: 9/4/2009
Issue release date: 1995

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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