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Vol. 110, No. 1, 1996
Issue release date: 1996
Section title: Original Paper
Int Arch Allergy Immunol 1996;110:52–56
(DOI:10.1159/000237310)

Cetirizine Exerts Anti-Inflammatory Effects on Human Neutrophils

Köller M.a · Hilger R.A.a · Rihoux J.P.b · König W.a
aMedizinische Mikrobiologie und Immunologie, AG Infektabwehrmechanismen, Ruhr-Universität Bochum, Germany; bUnion Chimique Beige, Brussels, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/9/1995
Accepted: 11/8/1995
Published online: 9/4/2009
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Leukotrienes are potent lipid mediators involved in acute and chronic inflammatory processes and allergic inflammation. Cetirizine is an H1-receptor antagonist used in the treatment of allergic symptoms. We analyzed the effect of cetirizine on the formation of leukotriene B4 (LTB4) after stimulation of human peripheral blood neutrophils. The inflammatory mediators were analyzed after cellular activation with different stimuli: the Ca ionophore A23187, which bypasses membranous signal transduction elements; the bacterial peptide formyl-methionine-leucyl-phenylalonine (fMLP), which activates cells by binding to a GTP-protein (G-protein)-coupled receptor, and with sodium fluoride (NaF), which directly activates G-proteins. After cellular preincubation with cetirizine, the amounts of LTB4 generated from neutrophil granulocytes decreased significantly when the cells were subsequently stimulated with either fMLP or NaF, in contrast to stimulations with the Ca ionophore. The data provide evidence that cetirizine exerts anti-inflammatory effects apart from H1 antagonism.

© 1996 S. Karger AG, Basel


  

Author Contacts

Correspondence to: Prof. Dr. W. König, Medizinische Mikrobiologie und Immunologie, AG Infektabwehrmechanismen, Ruhr-Universität Bochum, Universitätsstrasse 150, D–44780 Bochum (Germany)

  

Article Information

Received: May 9, 1995
Accepted after revision: November 8, 1995
Published online: September 04, 2009
Number of Print Pages : 5

  

Publication Details

International Archives of Allergy and Immunology

Vol. 110, No. 1, Year 1996 (Cover Date: 1996)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 5/9/1995
Accepted: 11/8/1995
Published online: 9/4/2009
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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