IgA and IgG antibody response of adult atopic dermatitis patients against neutral/acidic fractions of wheat, rye, barley and oats was analyzed utilizing an immunoblotting method. Moreover, the antibody response against ethanol-soluble fraction of wheat was examined with serum pools of healthy donors, atopic dermatitis patients and patients with dermatitis herpetiformis or adult celiac disease. All patient sera revealed polymorphic IgA and IgG binding to cereal peptides with molecular weights of 11–97 kD. The antibody staining was essentially identical with atopic dermatitis patients and controls. Patients with dermatitis herpetiformis or celiac disease showed more intensive staining with the ethanol extract of wheat and showed more IgA-stained bands in immunoblotting. It seems that the presence of IgA and IgG antibodies to different cereal antigens is a result of natural exposure and in atopic dermatitis displays little diagnostic significance, in contrast to antigliadin antibody response in dermatitis herpetiformis and celiac disease.
Correspondence to: Dr. Elina Varjonen, Department of Dermatology, Helsinki University Central Hospital, Meilahdentie2, FIN–00250 Helsinki (Finland)
Received: September 5, 1995
Accepted after revision: March 5, 1996
Published online: September 04, 2009
Number of Print Pages : 9
International Archives of Allergy and Immunology
Vol. 111, No. 1, Year 1996 (Cover Date: 1996)
Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA
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