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Vol. 111, No. 1, 1996
Issue release date: 1996
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Int Arch Allergy Immunol 1996;111:55–63
(DOI:10.1159/000237346)
Original Paper

IgA and IgG Binding Components of Wheat, Rye, Barley and Oats Recognized by Immunoblotting Analysis with Sera from Adult Atopic Dermatitis Patients

Varjonen E.a · Kalimo K.b · Savolainen J.c · Vainio E.b
aDepartment of Dermatology, Helsinki University Central Hospital, and Departments of bDermatology and cClinical Allergology, Turku University Central Hospital, Finland Int Arch Allergy Immunol 1996;111:55–63 (DOI:10.1159/000237346)

Abstract

IgA and IgG antibody response of adult atopic dermatitis patients against neutral/acidic fractions of wheat, rye, barley and oats was analyzed utilizing an immunoblotting method. Moreover, the antibody response against ethanol-soluble fraction of wheat was examined with serum pools of healthy donors, atopic dermatitis patients and patients with dermatitis herpetiformis or adult celiac disease. All patient sera revealed polymorphic IgA and IgG binding to cereal peptides with molecular weights of 11–97 kD. The antibody staining was essentially identical with atopic dermatitis patients and controls. Patients with dermatitis herpetiformis or celiac disease showed more intensive staining with the ethanol extract of wheat and showed more IgA-stained bands in immunoblotting. It seems that the presence of IgA and IgG antibodies to different cereal antigens is a result of natural exposure and in atopic dermatitis displays little diagnostic significance, in contrast to antigliadin antibody response in dermatitis herpetiformis and celiac disease.

 goto top of outline Author Contacts

Correspondence to: Dr. Elina Varjonen, Department of Dermatology, Helsinki University Central Hospital, Meilahdentie2, FIN–00250 Helsinki (Finland)


 goto top of outline Article Information

Received: September 5, 1995
Accepted after revision: March 5, 1996
Published online: September 04, 2009
Number of Print Pages : 9


 goto top of outline Publication Details

International Archives of Allergy and Immunology

Vol. 111, No. 1, Year 1996 (Cover Date: 1996)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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