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Vol. 111, No. 1, 1996
Issue release date: 1996
Section title: Original Paper
Int Arch Allergy Immunol 1996;111:77–82
(DOI:10.1159/000237349)

Culture and IgE Synthesis of Nasal B Cells

Zürcher A.W.a · Derer T.a · Lang A.B.b · Stadler B.M.a
aInstitute of Immunology and Allergology, Inselspital, and bSwiss Serum and Vaccine Institute, Bern, Switzerland

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/28/1995
Accepted: 3/19/1996
Published online: 9/4/2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

The interplay of inflammatory cells, mediators and cytokines during type I allergic reactions in the nose is well described. But even though allergen-specific IgE is known to play a central role for the induction of these events, little is known about nasal B cells and their role in the local allergic reaction. It was the aim of the present study to examine the possibility to isolate and culture B cells from the nose. For this purpose allergic and nonallergic volunteers were challenged by nasal provocation with allergen. Cells were collected sequentially after nasal provocation by nasal lavage, B cells grown in the CD40 system and IgE production assessed by enzyme-linked filter spot assay and radioimmunoassay. IgE-producing B cells were detected after culture of nasal lavage cells in the CD40 system. Elevated levels of IgE were measured in culture supernatants from cells collected during the late-phase allergic reaction. We conclude that B cells can be isolated from the nose and may serve as an interesting source of B cells after in vivo contact with antigen.

© 1996 S. Karger AG, Basel


  

Author Contacts

Correspondence to: A. W. Zürcher, Institute of Immunology and Allergology, Inselspital, CH–3010 Bern (Switzerland)

  

Article Information

Received: December 28, 1995
Accepted after revision: March 19, 1996
Published online: September 04, 2009
Number of Print Pages : 6

  

Publication Details

International Archives of Allergy and Immunology

Vol. 111, No. 1, Year 1996 (Cover Date: 1996)

Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 12/28/1995
Accepted: 3/19/1996
Published online: 9/4/2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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