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Table of Contents
Vol. 112, No. 3, 1997
Issue release date: 1997
Section title: Original Paper
Int Arch Allergy Immunol 1997;112:212–217
(DOI:10.1159/000237456)

In vitro Lymphocyte Proliferation as Compared to Patch Test Using Gold, Palladium and Nickel

Cederbrant K.a,b · Hultman P.b · Marcusson J.A.c · Tibbling L.d
aDepartment of Surgery and bDepartment of Pathology I, Linköping University, Linköping, cDepartment of Dermatology, Huddinge Hospital, Huddinge, and dDepartment of Otorhinolaryngology, Linköping University, Linköping, Sweden

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 20, 1996
Accepted: November 11, 1996
Published online: September 04, 2009
Issue release date: 1997

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: A conventional lymphocyte transformation test (LTT) was compared to the commercially available MELISA® (memory lymphocyte immuno-stimulation assay), a lymphoproliferative assay that has been suggested to be a valuable instrument for the diagnosis of metal allergy. Sensitivity and specificity of the two assays were calculated using a patch test as a reference method. Methods: 34 patients were patch-tested for gold sodium thiosulfate, palladium chloride and nickel sulfate, and the lymphocyte proliferation to these metals was tested in vitro using mononuclear cells from peripheral blood. Results: No significant differences regarding sensitivity and specificity were found between MELISA and conventional LTT. The sensitivity varied between 55 and 95% and the specificity between 17 and 79%. Conclusions: The low specificity of the two in vitro assays suggests that they are not useful for diagnosis of contact allergy to the metals gold, palladium and nickel, since a large number of false-positive results will be obtained.

© 1997 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: May 20, 1996
Accepted: November 11, 1996
Published online: September 04, 2009
Issue release date: 1997

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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