The ‘Atopy Patch Test’ in Evaluating the Role of Aeroallergens in Atopic EczemaRing J. · Darsow U. · Gfesser M. · Vieluf D.
aKlinik und Poliklinik für Dermatologie und Allergologie Biederstein, Technical University Munich and bHautklinik und Allergie-Abteilung, University Hospital Eppendorf, Hamburg, Germany
The atopy patch test (APT) is a procedure involving epicutaneous patch tests with allergens known to elicit IgE-mediated reactions and the evaluation of eczematous skin lesions. APT can be performed on normal uninvolved skin without artificial manipulations such as tape stripping or use of irritants. APT has been standardized regarding the use of vehicle and dose response relationships. In several studies, approximately two thirds of patients with atopic eczema (AE) showed positive APT reactions to aeroallergens, most frequently to house dust mite. Positive APT reactions were significantly more frequent in patients with a typical air-exposed eczematous distribution pattern. Using evaporimetry to study transepidermal water loss, allergen-induced disturbance of epidermal barrier functions was found to be significantly more pronounced on APT reactions compared to classical contact allergy patch test sites in the same individual. It has been shown that with APT eczematous skin lesions can be elicited by skin contact with aeroallergens, at least in a subgroup of patients with AE, and thereby, that IgE-mediated allergy does play a role in the etiopathophysiology of this disease. Future studies should help to bring this test into clinical routine in order to establish an equivalent for ‘skin provocation’ comparable to nasal and bronchial provocation tests in respiratory allergy.
Correspondence to: Prof. Dr. Johannes Ring, Klinik und Poliklinik für Dermatologie und Allergologie am Biederstein, Technische Universität München, Biedersteinerstrasse 29, D–80802 München (Germany), Tel. 0049 89 38 49 4, Fax 0049 89 38 49 31 71
Published online: September 04, 2009
Number of Print Pages : 5
International Archives of Allergy and Immunology
Vol. 113, No. 1-3, Year 1997 (Cover Date: 1997)
Journal Editor: Valenta R. (Vienna)
ISSN: 1018-2438 (Print), eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA