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Table of Contents
Vol. 26, No. 2, 2009
Issue release date: October 2009
Section title: Original Paper
Fetal Diagn Ther 2009;26:81–84
(DOI:10.1159/000238114)

Value of Amniocentesis versus Fetal Tissue for Cytogenetic Analysis in Cases of Fetal Demise

Bryant Borders A.E.a · Greenberg J.b · Plaga S.b · Shepard-Hinton M.b · Yates C.b · Elias S.b · Shulman L.P.b
aDivision of Maternal-Fetal Medicine, bDivision of Reproductive Genetics, Department of Obstetrics and Gynecology, Feinberg School of Medicine, Northwestern University, Chicago, Ill., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 22, 2008
Accepted: December 10, 2008
Published online: September 11, 2009
Issue release date: October 2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT

Abstract

Objective: Use of fetal tissue for cytogenetic analysis in cases of second- and third-trimester fetal demise frequently results in unacceptably high failure rates. We reviewed our ongoing use of amniocentesis prior to uterine evacuation to determine if this provided a better source of cells for cytogenetic analysis. Methods: We compared cytogenetic results using fetal tissues obtained following uterine evacuation to our ongoing use of amniotic fluid cell obtained by transabdominal amniocentesis prior to uterine evacuation from 2003 to 2008. Results: In 49 of the 63 cases evaluated by fetal tissue biopsies performed after uterine evacuation, a karyotypic analysis was obtained (77.8%). Among the 38 cases evaluated by amniocentesis, an amniotic fluid sample and fetal cytogenetic results were obtained in all 38 (100%) cases. Conclusion: Our findings indicate that amniocentesis is a more reliable source of cytogenetic information than fetal tissue in cases of second- and third-trimester fetal demise.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: September 22, 2008
Accepted: December 10, 2008
Published online: September 11, 2009
Issue release date: October 2009

Number of Print Pages: 4
Number of Figures: 0
Number of Tables: 0

ISSN: 1015-3837 (Print)
eISSN: 1421-9964 (Online)

For additional information: http://www.karger.com/FDT


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