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Vol. 29, No. 1, 1983
Issue release date: 1983
Section title: Pharmacology
Chemotherapy 1983;29:1–3
(DOI:10.1159/000238165)

Pharmacokinetics of L/105, a New Rifamycin, in Rats and Dogs, after Oral Administration

Venturini A.P.
Research Laboratories, Alfa Farmaceutici s.p.a. Bologna, Italy

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology

Published online: 9/8/2009
Issue release date: 1983

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

The absorption and tissue distribution of a new rifamycin, L/105, which chemically is 4-deoxy-4’-methylpyrido [l’,2’-l,2] imidazo [5,4 C] rifamycin SV, were studied in rats after oral administration of 100 mg/kg. This study showed that L/105, contrary to what was observed for rifampicin, was practically not absorbed: neither serum nor significant tissue levels were evidenced. Also in dogs, after oral administration of L/105 in a single dose (25 mg/kg) and a multiple dosage (10 mg/kg/day, for 8 days), no traces of the compound were detected in the serum. The elimination was investigated in the rat: the highest recovery of L/105 (more than 50% of the administered dose) was in feces after 72 h, hardly any traces were found in urine.

© 1983 S. Karger AG, Basel


  

Author Contacts

A.P. Venturini, Research Laboratories, Alfa Farmaceutici s.p.a., Via Ragazzi del ‘99 n. 5, I-40133 Bologna (Italy)

  

Article Information

Published online: September 08, 2009
Number of Print Pages : 3

  

Publication Details

Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)

Vol. 29, No. 1, Year 1983 (Cover Date: 1983)

Journal Editor: Sörgel F. (Nürnberg-Heroldsberg)
ISSN: 0009-3157 (Print), eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


Article / Publication Details

First-Page Preview
Abstract of Pharmacology

Published online: 9/8/2009
Issue release date: 1983

Number of Print Pages: 3
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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