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Table of Contents
Vol. 29, No. 2, 1983
Issue release date: 1983
Section title: Pharmacology
Chemotherapy 1983;29:73–79
(DOI:10.1159/000238178)

Cefotaxime: Pharmacokinetics and in vitro Antibacterial Activity of Serum and Urine in Normal Human Volunteers

Plouffe J.F. · Perkins R.L. · Fass R.J. · Prior R.B. · Bernstein B. · Ho I.
aDivision of Infectious Diseases, Department of Medicine, The Ohio State University College of Medicine Columbus, Ohio, USA; bHoechst Roussell Pharmaceuticals, Somerville, N.J., USA

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Article / Publication Details

First-Page Preview
Abstract of Pharmacology

Published online: 9/8/2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

The pharmacokinetic and antibacterial properties of cefotaxime were determined in normal adult volunteers. Single doses of 250, 500, 1,000 and 2,000 mg were evaluated following 5- and 20-min intravenous (i.v.) infusions and intramuscular (i.m.) administration. Cefotaxime was well tolerated and mean peak serum levels exceeded the minimum inhibition concentration (MIC) values for a wide spectrum of potential bacterial pathogens. Approximately 48% of the i.v. doses was excreted renally; average volume of distribution was 30% of body weight and the t½ was about 1 h. Cefotaxime was rapidly absorbed following i.m. injection with maximum serum concentrations occurring at approximately 0.6 h. Serum and urine antibacterial activity reflected the concentration of cefotaxime and MIC of the bacterial pathogens tested.


  

Author Contacts

Dr. Joseph F. Plouffe, Division of Infectious Diseases, Department of Medicine, The Ohio State University, College of Medicine, Columbus, OH 43210 (USA)

  

Article Information

Published online: September 08, 2009
Number of Print Pages : 7

  

Publication Details

Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)

Vol. 29, No. 2, Year 1983 (Cover Date: 1983)

Journal Editor: Sörgel F. (Nürnberg-Heroldsberg)
ISSN: 0009-3157 (Print), eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


Article / Publication Details

First-Page Preview
Abstract of Pharmacology

Published online: 9/8/2009

Number of Print Pages: 7
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


Copyright / Drug Dosage

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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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