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Table of Contents
Vol. 115, No. 2, 1998
Issue release date: February 1998
Section title: Original Paper
Int Arch Allergy Immunol 1998;115:157–161
(DOI:10.1159/000023896)

Allergen-Specific Nasal Challenge: Response Kinetics of Clinical and Inflammatory Events to Rechallenge

Ciprandi G.a · Ricca V.b · Landi M.b · Passalacqua G.a · Bagnasco M.a · Canonica G.W.a
aAllergy and Clinical Immunology Service, Department of Internal Medicine, University of Genoa, and bKoelliker Hospital, Turin, Italy

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: January 26, 1998
Issue release date: February 1998

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Allergen-specific nasal challenge is a valid and reliable tool for studying the pathophysiological mechanisms involved in allergic inflammation. Nasal challenge induces an immediate clinical response in allergic subjects and a concomitant appearance of an inflammatory infiltrate. The mucosal inflammation may persist up to 48–72 h after allergen exposure. If the subjects are rechallenged within this period the response is more pronounced: the so-defined priming effect. The aim of the study was to evaluate the effects of the nasal rechallenge, performed at different time intervals: 3 days, 1, 2 and 4 weeks after the first challenge. Forty allergic subjects underwent two nasal challenges: at baseline and after the periods mentioned above (10/group). Symptoms and inflammatory cells (eosinophils and neutrophils recovered by nasal brushing) were assessed. The 3-day-interval group showed a hyperreactive response (priming effect), the 1- and 4-week-interval groups showed a response similar to baseline, and the 2-week-interval group showed a hyporeactive response (‘tolerogenic effect’). The last phenomenon may be due to a possible immunologic response similar to that achievable during local specific immunotherapy. The present results further elucidate the kinetics of allergen-driven inflammatory events and highlight the importance of the time period chosen for rechallenge. The latter fact may be of primary importance in clinical trials involving specific challenge.


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: January 26, 1998
Issue release date: February 1998

Number of Print Pages: 5
Number of Figures: 4
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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