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Vol. 115, No. 3, 1998
Issue release date: March 1998
Section title: Review
Int Arch Allergy Immunol 1998;115:179–190
(DOI:10.1159/000023899)

Role of T Cells in Atopic Dermatitis

New Aspects on the Dynamics of Cytokine Production and the Contribution of Bacterial Superantigens

Herz U.a · Bunikowski R.b · Renz H.a
aInstitute of Clinical Chemistry and Biochemistry, and bDepartment of Pediatric Pneumology and Immunology of the Charité-Virchow Klinikum, of the Humboldt University, Berlin, Germany

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 3/5/1998
Issue release date: March 1998

Number of Print Pages: 12
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease. Influx of activated T cells into the skin lesions represents a hallmark in AD. Recent results indicate a dynamic T-cell-derived cytokine production in AD. In addition to the well-known TH-2 component, chronic lesions and late-phase allergic responses are characterized by an TH-1/TH-0 cytokine pattern. Although there is no doubt that aeroallergens can contribute to the elicitation of acute- and late-phase allergic responses in AD, their role in the immunopathogenesis is controversally discussed. Recent attention has been given to the long-known phenomenon of persistent colonization of AD skin with S. aureus and the potential role of S. aureus-derived superantigens. Evidence from several in vitro and in vivo studies suggests that such bacterial superantigens have the potency to trigger chronic T-cell-mediated skin inflammation. Although these data are certainly suggestive, further clinical studies are required to elucidate the role of bacterial superantigens in initiation, maintenance and, especially, chronicity of skin inflammation.


  

Author Contacts

Correspondence to: Dr. Harald Renz
Institute of Clinical Chemistry/Biochemistry
Charité-Virchow Klinikum
D-13353 Berlin (Germany)
Tel. +49-30-450 69778, Fax +49-30-450 69900

  

Article Information

Number of Print Pages : 12
Number of Figures : 2, Number of Tables : 3, Number of References : 142

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950

Vol. 115, No. 3, Year 1998 (Cover Date: March 1998)

Journal Editor: G. Wick, Innsbruck
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/journals/iaa


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 3/5/1998
Issue release date: March 1998

Number of Print Pages: 12
Number of Figures: 2
Number of Tables: 3

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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