Atopic dermatitis (AD) is a chronically relapsing inflammatory skin disease. Influx of activated T cells into the skin lesions represents a hallmark in AD. Recent results indicate a dynamic T-cell-derived cytokine production in AD. In addition to the well-known TH-2 component, chronic lesions and late-phase allergic responses are characterized by an TH-1/TH-0 cytokine pattern. Although there is no doubt that aeroallergens can contribute to the elicitation of acute- and late-phase allergic responses in AD, their role in the immunopathogenesis is controversally discussed. Recent attention has been given to the long-known phenomenon of persistent colonization of AD skin with S. aureus and the potential role of S. aureus-derived superantigens. Evidence from several in vitro and in vivo studies suggests that such bacterial superantigens have the potency to trigger chronic T-cell-mediated skin inflammation. Although these data are certainly suggestive, further clinical studies are required to elucidate the role of bacterial superantigens in initiation, maintenance and, especially, chronicity of skin inflammation.
Correspondence to: Dr. Harald Renz
Institute of Clinical Chemistry/Biochemistry
D-13353 Berlin (Germany)
Tel. +49-30-450 69778, Fax +49-30-450 69900
Number of Print Pages : 12
Number of Figures : 2, Number of Tables : 3, Number of References : 142
International Archives of Allergy and Immunology
Vol. 115, No. 3, Year 1998 (Cover Date: March 1998)
Journal Editor: G. Wick, Innsbruck
ISSN: 1018–2438 (print), 1423–0097 (Online)
For additional information:http://www.karger.com/journals/iaa
Article / Publication Details
Published online: 3/5/1998
Issue release date: March 1998
Number of Print Pages: 12
Number of Figures: 2
Number of Tables: 3
ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA
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