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Table of Contents
Vol. 42, No. 6, 1996
Issue release date: 1996
Section title: Experimental Chemotherapy
Chemotherapy 1996;42:459–464
(DOI:10.1159/000239480)

Immunomodulatory Action of Levofloxacin on Cytokine Production by Human Peripheral Blood Mononuclear Cells

Yoshimura T.a · Kurita C.a · Usami E.a · Nakao T.a · Watanabe S.a · Kobayashi J.a · Yamazaki F.a · Nagai H.b
aPharmaceutical Division, Ogaki Municipal Hospital, Ogaki, and bDepartment of Pharmacology, Gifu Pharmaceutical University, Gifu, Japan

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Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Published online: 9/11/2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE

Abstract

Levofloxacin (LVFX), the bacteriologically active isomer of ofloxacin, is a fluorinated quinolone. LVFX suppressed the proliferative activity of peripheral blood mononuclear cells (PBMC) stimulated with phytohemagglutinin (PHA). LVFX increased interleukin-2 (IL-2) production by PBMC stimulated with PHA in a dose-dependent manner, with more than 10 μg/ml of LVFX causing a significant increase. The granulocyte-macrophage colony-stimulating factor and soluble IL-2 receptor production by PHA-stimulated PBMC was suppressed at high concentrations of LVFX. Interleukin-1β production by lipopolysaccharide-stimulated PBMC was suppressed in a concentration-dependent manner by LVFX, and tumor necrosis factor-α production was suppressed at only the highest concentration. In contrast, interleukin-8 production was little affected by LVFX. These results show that LVFX has an immunomodulatory action on cytokines production by PBMC independent of its antimicrobial activity.

© 1996 S. Karger AG, Basel


  

Author Contacts

Dr. Tomoaki Yoshimura, Pharmaceutical Division, Ogaki Municipal Hospital, 4-86 Minaminokawa-cho, Ogaki, Gifu 503 (Japan)

  

Article Information

Published online: September 11, 2009
Number of Print Pages : 6

  

Publication Details

Chemotherapy (International Journal of Experimental and Clinical Chemotherapy)

Vol. 42, No. 6, Year 1996 (Cover Date: 1996)

Journal Editor: Sörgel F. (Nürnberg-Heroldsberg)
ISSN: 0009-3157 (Print), eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


Article / Publication Details

First-Page Preview
Abstract of Experimental Chemotherapy

Published online: 9/11/2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 0009-3157 (Print)
eISSN: 1421-9794 (Online)

For additional information: http://www.karger.com/CHE


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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