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Vol. 22, No. 6, 2009
Issue release date: November 2009
Section title: Original Paper
Skin Pharmacol Physiol 2009;22:299–304
(DOI:10.1159/000241299)

Skin Penetration of Epigallocatechin-3-Gallate and Quercetin from Green Tea and Ginkgo biloba Extracts Vehiculated in Cosmetic Formulations

dal Belo S.E. · Gaspar L.R. · Maia Campos P.M.B.G. · Marty J.-P.
aFaculdade de Ciências Farmacêuticas de Ribeirão Preto, University of São Paulo, São Paulo, Brazil; bFaculté de Pharmacie, University Paris-South (XI), Paris, France

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/29/2008
Accepted: 7/10/2009
Published online: 9/25/2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP

Abstract

Green tea (Camellia sinensis) and Ginkgo biloba extracts in cosmetic formulations have been suggested to protect the skin against UV-induced damage and skin ageing. Thus, it is very important to assess the human skin penetration of their major flavonoids to verify if they penetrate and remain in the skin to exert their proposed effects. The aim of this study was to evaluate the human skin penetration of epigallocatechin-3-gallate (EGCG) and quercetin from green tea and G. biloba extracts vehiculated in cosmetic formulations. This study was conducted with fresh dermatomed human Caucasian skin from abdominal surgery mounted on static Franz diffusion cells. Skin samples were mounted between two diffusion half-cells and 10 mg/cm2 of formulations supplemented with 6% of green tea or G. biloba extract were applied on the skin surface. The receptor fluid was removed after 6 and 24 h and analyzed by high-performance liquid chromatography for the quantification of the flavonoids. The stratum corneum was removed by tape stripping and immersed in methanol and the epidermis was mechanically separated from the dermis and triturated in methanol to extract EGCG and quercetin. The results showed that the flavonoids under study penetrated into the skin, without reaching the receptor fluid. The majority of EGCG was quantified in the stratum corneum (0.87 μg/cm2), which was statistically higher than the EGCG concentrations found in viable epidermis (0.54 μg/cm2) and in the dermis (0.38 μg/cm2). The majority of quercetin was quantified in the viable epidermis (0.23 μg/cm2), which was statistically higher than the EGCG concentration found in the stratum corneum layer (0.17 μg/cm2). Finally, it can be concluded that EGCG and quercetin from green tea and G. biloba extracts vehiculated in cosmetic formulations presented good skin penetration and retention, which can favor their skin effects.


  

Author Contacts

Patrícia Maria Berardo Gonçalves Maia Campos
University of São Paulo, Faculty of Pharmaceutical Sciences of Ribeirão Preto
Department of Pharmaceutical Sciences, Avenida do Café s/n°
Campus Universitário da USP, Ribeirão Preto, SP 14040–903 (Brazil)
Tel. +55 16 3602 4307, E-Mail pmcampos@usp.br

  

Article Information

Received: September 29, 2008
Accepted after revision: July 10, 2009
Published online: September 25, 2009
Number of Print Pages : 6
Number of Figures : 3, Number of Tables : 1, Number of References : 18

  

Publication Details

Skin Pharmacology and Physiology (Journal of Pharmacological and Biophysical Research)

Vol. 22, No. 6, Year 2009 (Cover Date: November 2009)

Journal Editor: Lademann J. (Berlin)
ISSN: 1660-5527 (Print), eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: 9/29/2008
Accepted: 7/10/2009
Published online: 9/25/2009

Number of Print Pages: 6
Number of Figures: 3
Number of Tables: 1

ISSN: 1660-5527 (Print)
eISSN: 1660-5535 (Online)

For additional information: http://www.karger.com/SPP


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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