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Vol. 118, No. 2-4, 1999
Issue release date: February–April 1999
Section title: Clinical Allergy: Rhinitis and Asthma
Int Arch Allergy Immunol 1999;118:375–379
(DOI:10.1159/000024141)

Regulation of Proinflammatory Cytokines in Seasonal Allergic Rhinitis

Bachert C. · van Kempen M. · van Cauwenberge P.
ENT Department, University Hospital Ghent, Belgium

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Article / Publication Details

First-Page Preview
Abstract of Clinical Allergy: Rhinitis and Asthma

Published online: 4/23/1999

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Background: Mediators and cytokines have been demonstrated to be released due to nasal allergen exposure in sensitized subjects, but little is known about the release of cytokines and their antagonists under natural conditions. Methods: Mediators – histamine, eosinophilic cationic protein (ECP), leukotrienes (LT) C4/ D4/E4 – and cytokines – interleukin (IL)–1β, IL–8, IL–1 receptor antagonist (ra) – were measured in nasal secretions throughout the grass pollen season (6 visits) and for 6 weeks thereafter (3 visits) in patients with seasonal allergic rhinitis (n = 13) and compared to controls (n = 12). A second study was performed comparing nasal secretions of 13 subjects allergic to house dust mite to 8 controls. Results: Compared to controls, leukotrienes and ECP were significantly elevated at nearly all time points in and postseason in the allergic group. Whereas IL–1β was significantly elevated throughout the study period, IL–1ra was significantly decreased from visit 1 to 3. IL–8 showed no increase compared to controls. Data from subjects with perennial allergic rhinitis supported these findings and additionally demonstrated decreased concentrations of IL–8 and myeloperoxidase in secretions compared to controls. Conclusion: Allergic rhinitis represents a persistent inflammation in terms of an activation of eosinophils and constant upregulation of the proinflammatory cytokine IL–1β in the pollen season and thereafter. We additionally could demonstrate a dysfunction of the anti–inflammatory capacity, i.e. IL–1ra, a naturally occurring antagonist. Persistent inflammation may furthermore lead to the dysregulation of local cellular immunity by reducing the number and activity of neutrophils on the mucosal surface.


  

Author Contacts

Correspondence to: Prof. Dr. Claus Bachert
ENT Department, University Hospital Ghent, Belgium
De Pintelaan 185, B–9000 Ghent (Belgium)
Tel. +32 9 240 23 63, Fax +32 9 240 49 93
E–Mail claus.bachert@rug.ac.be

  

Article Information

Number of Print Pages : 5
Number of Figures : 2, Number of Tables : 0, Number of References : 8

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950

Vol. 118, No. 2-4, Year 1999 (Cover Date: February-April 1999)

Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/journals/iaa


Article / Publication Details

First-Page Preview
Abstract of Clinical Allergy: Rhinitis and Asthma

Published online: 4/23/1999

Number of Print Pages: 5
Number of Figures: 2
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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