Electron–microscopic (EM) analysis preceded crystallographic analysis [1, 2]of Igs by over a decade and was for a time the only direct way of analyzing their 3–D molecular structure. Once the X–ray structures were deduced, the role of EM gradually shifted from gross structural analysis to the addressing of more sophisticated structural and functional questions. EM remains a vital adjunct to the many physicochemical, biochemical, and serological tools brought to bear on these remarkable molecules as we try to relate form to function. In this review I will highlight some of the many contributions that have been made possible by virtue of being able to ‘see’ Ig molecules and immune complexes.
Correspondence to: Dr. Kenneth H. Roux
Department of Biological Science
Florida State University
Tallahassee, FL 32306 – 4370 (USA)
Tel. +1 (850) 644 5037, Fax +1 (850) 644 0481
Number of Print Pages : 15
Number of Figures : 19, Number of Tables : 1, Number of References : 80
International Archives of Allergy and Immunology
Vol. 120, No. 2, Year 1999 (Cover Date: October 1999)
Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)
For additional information:http://www.karger.com/journals/iaa
Article / Publication Details
Published online: 10/15/1999
Issue release date: October 1999
Number of Print Pages: 15
Number of Figures: 19
Number of Tables: 1
ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)
For additional information: http://www.karger.com/IAA
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