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Vol. 120, No. 2, 1999
Issue release date: October 1999
Section title: Review
Int Arch Allergy Immunol 1999;120:85–99
(DOI:10.1159/000024226)

Immunoglobulin Structure and Function as Revealed by Electron Microscopy

Roux K.H.
Department of Biological Science, Florida State University, Tallahassee, Fla., USA

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 10/15/1999
Issue release date: October 1999

Number of Print Pages: 15
Number of Figures: 19
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Electron–microscopic (EM) analysis preceded crystallographic analysis [1, 2]of Igs by over a decade and was for a time the only direct way of analyzing their 3–D molecular structure. Once the X–ray structures were deduced, the role of EM gradually shifted from gross structural analysis to the addressing of more sophisticated structural and functional questions. EM remains a vital adjunct to the many physicochemical, biochemical, and serological tools brought to bear on these remarkable molecules as we try to relate form to function. In this review I will highlight some of the many contributions that have been made possible by virtue of being able to ‘see’ Ig molecules and immune complexes.


  

Author Contacts

Correspondence to: Dr. Kenneth H. Roux
Department of Biological Science
Florida State University
Tallahassee, FL 32306 – 4370 (USA)
Tel. +1 (850) 644 5037, Fax +1 (850) 644 0481

  

Article Information

Number of Print Pages : 15
Number of Figures : 19, Number of Tables : 1, Number of References : 80

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950

Vol. 120, No. 2, Year 1999 (Cover Date: October 1999)

Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/journals/iaa


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 10/15/1999
Issue release date: October 1999

Number of Print Pages: 15
Number of Figures: 19
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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