In structural brain development eight interrelated but distinguishable events can be recognized: (1) neuronal induction, (2) neuroblast proliferation, (3) neuronal migration, (4) neuronal selective aggregation, (5) neuronal differentiation and formation of specific patterns of connection, (6) neuronal death, (7) selective synapse elimination and (8) myelination. The basic mechanisms regulating these developmental events are genetically determined but at any stage of development epigenetic and environmental factors modulate the genetic regulation. This paper reviews representative samples of work in animal experiments and knowledge in human fetal brain development by several authors.
Dr. Norbert Herschkowitz, Medizinische Universitäts-Kinderklinik, Inselspital Bern, CH-3010 Bern (Switzerland)
Published online: September 25, 2009
Number of Print Pages : 19
Neonatology (Fetal and Neonatal Research)
Vol. 54, No. 1, Year 1988 (Cover Date: 1988)
Journal Editor: Halliday H.L. (Belfast), Speer C.P. (Würzburg)
ISSN: 1661-7800 (Print), eISSN: 1661-7819 (Online)
For additional information: http://www.karger.com/NEO
Copyright / Drug Dosage
Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.