Characterization of T Cell Subpopulations Involved in the Pathogenesis of Asthma and Allergic DiseasesYssel H. · Groux H.
aINSERM U454, Hôpital Arnaud de Villeneuve, Montpellier, and bINSERM U343, Hôpital de l’Archet, Nice, France
Allergic asthma is a complex and heterogeneous disease which is characterized by intermittent reversible airway obstruction, chronic inflammation of the airways, bronchial hyperreactivity and an infiltration of lymphocytes and eosinophils into the airway submucosa. Animal models and clinical studies in humans have indicated an important role for T helper type 2 lymphocytes, producing IL-4, IL-5 and IL-13, in the pathogenesis of this disorder. However, although IL-4 and IL-13 have strong anti-inflammatory properties, the physiologic anti-inflammatory Th2 response does not seem to be operational in allergic asthma. Moreover, the induction of a Th1 response seems to aggravate, rather than ameliorate, its inflammatory character. This article will focus on the involvement of T lymphocyte subpopulations in the pathogenesis of allergic asthma and allergic diseases. In addition, a potential role of the subpopulation(s) of T regulatory cells in the induction and/or maintaince of the disease process will be discussed.
Correspondence to: Dr. Hans Yssel
INSERM U454, Hôpital Arnaud de Villeneuve
371 Avenue Doyen Gaston Giraud
F–34295 Montpellier Cedex 5 (France)
Tel./Fax +33 4 67 41 52 12, E-Mail firstname.lastname@example.org
Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 0, Number of References : 74
International Archives of Allergy and Immunology
Vol. 121, No. 1, Year 2000 (Cover Date: January 2000)
Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)
For additional information:http://www.karger.com/journals/iaa