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Vol. 121, No. 1, 2000
Issue release date: January 2000
Section title: Review
Int Arch Allergy Immunol 2000;121:10–18
(DOI:10.1159/000024292)

Characterization of T Cell Subpopulations Involved in the Pathogenesis of Asthma and Allergic Diseases

Yssel H. · Groux H.
aINSERM U454, Hôpital Arnaud de Villeneuve, Montpellier, and bINSERM U343, Hôpital de l’Archet, Nice, France

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 2/3/2000

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

Allergic asthma is a complex and heterogeneous disease which is characterized by intermittent reversible airway obstruction, chronic inflammation of the airways, bronchial hyperreactivity and an infiltration of lymphocytes and eosinophils into the airway submucosa. Animal models and clinical studies in humans have indicated an important role for T helper type 2 lymphocytes, producing IL-4, IL-5 and IL-13, in the pathogenesis of this disorder. However, although IL-4 and IL-13 have strong anti-inflammatory properties, the physiologic anti-inflammatory Th2 response does not seem to be operational in allergic asthma. Moreover, the induction of a Th1 response seems to aggravate, rather than ameliorate, its inflammatory character. This article will focus on the involvement of T lymphocyte subpopulations in the pathogenesis of allergic asthma and allergic diseases. In addition, a potential role of the subpopulation(s) of T regulatory cells in the induction and/or maintaince of the disease process will be discussed.


  

Author Contacts

Correspondence to: Dr. Hans Yssel
INSERM U454, Hôpital Arnaud de Villeneuve
371 Avenue Doyen Gaston Giraud
F–34295 Montpellier Cedex 5 (France)
Tel./Fax +33 4 67 41 52 12, E-Mail yssel@montp.inserm.fr

  

Article Information

Number of Print Pages : 9
Number of Figures : 1, Number of Tables : 0, Number of References : 74

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950

Vol. 121, No. 1, Year 2000 (Cover Date: January 2000)

Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/journals/iaa


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 2/3/2000

Number of Print Pages: 9
Number of Figures: 1
Number of Tables: 0

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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