Anemia of Chronic Disease (Anemia of Inflammation)Agarwal N. · Prchal J.T.
aDivision of Hematology and Oncology, University of Utah School of Medicine and Veterans Affairs Hospital, and bARUP Laboratories, Salt Lake City, Utah, USA
Mild-to-moderate anemia often develops in the setting of acute or chronic immune activation and is termed anemia of chronic disease (ACD) or anemia of inflammation. Anemia of chronic disease is the second most common type of anemia (after anemia of iron deficiency) and results in increased morbidity and mortality of the underlying disease. Anemia of chronic disease is mediated by inflammatory cytokines and is characterized by low serum iron (hypoferremia) and often increased reticuloendothelial stores of iron. Hepcidin is the master regulator of iron homeostasis and its synthesis is inhibited by iron deficiency and stimulated by inflammation. The serum hepcidin level is useful in identifying iron deficiency in patients with ACD. Successful treatment of the underlying disease improves ACD. If that is not possible and if anemia is symptomatic, treatment with erythropoietic agents, supplemented with iron if necessary, is helpful in many cases.
Prof. Josef T. Prchal, MD
Division of Hematology
30 North 1900 East, SOM 5C402
Salt Lake City, UT 84132 (USA)
Tel. +1 801 581 4220, Fax +1 801 585 3432, E-Mail firstname.lastname@example.org
Published online: November 10, 2009
Number of Print Pages : 6
Number of Figures : 0, Number of Tables : 1, Number of References : 45
Vol. 122, No. 2-3, Year 2009 (Cover Date: November 2009)
Journal Editor: Ben-Bassat I. (Qiryat-Ono)
ISSN: 0001-5792 (Print), eISSN: 1421-9662 (Online)
For additional information: http://www.karger.com/AHA