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Vol. 123, No. 2, 2000
Issue release date: October 2000
Section title: Review
Int Arch Allergy Immunol 2000;123:107–119
(DOI:10.1159/000024441)

The Th2 Cytokine Environment of the Placenta

Dealtry G.B. · O’Farrell M.K. · Fernandez N.
Department of Biological Sciences, University of Essex, Colchester, UK

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Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 10/25/2000

Number of Print Pages: 13
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA

Abstract

It is now accepted that local changes to the balance of Th1/Th2-type cytokines occur during pregnancy within the maternal uterus and fetoplacental unit. These changes in cytokine profiles contribute to implantation of the embryo, development of the placenta, and survival of the fetus to term. Overall within the placenta there is a bias in the ratio of Th1:Th2 cytokines towards the Th2-type cytokines. However, there are specific fluctuations in this balance at implantation and during the initiation of parturition. The predominant cytokines at each stage of gestation function both to limit maternal immune rejection of the semi-allogeneic embryo/fetus, especially at the maternofetal interface; and to facilitate the on-going physiological processes within the maternal reproductive tract. These two, at times conflicting, roles are discussed in this review, with key evidence concerning cytokine expression and function from mouse and humans.


  

Author Contacts

Correspondence to: Dr. Gillian Dealtry
Department of Biological Sciences, University of Essex
Central Campus, Wivenhoe Park
Colchester CO4 3SQ (UK)
Tel. +44 1206 873 333, Fax +44 1206 872 592

  

Article Information

Number of Print Pages : 13
Number of Figures : 1, Number of Tables : 1, Number of References : 91

  

Publication Details

International Archives of Allergy and Immunology
Founded 1950

Vol. 123, No. 2, Year 2000 (Cover Date: October 2000)

Journal Editor: D. Kraft, Vienna
ISSN: 1018–2438 (print), 1423–0097 (Online)

For additional information:http://www.karger.com/journals/iaa


Article / Publication Details

First-Page Preview
Abstract of Review

Published online: 10/25/2000

Number of Print Pages: 13
Number of Figures: 1
Number of Tables: 1

ISSN: 1018-2438 (Print)
eISSN: 1423-0097 (Online)

For additional information: http://www.karger.com/IAA


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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