In vitro, bilirubin is a strong antioxidant, but in vivo its capacity to act as a scavenger of toxic oxygen radicals remains poorly documented. The aim of this study was to evaluate if bilirubin had antioxidant properties in jaundiced infants. The antioxidant capacity of neonatal plasma was measured in Trolox equivalents (TEAC, mmol/l) and correlated in vitro with plasma bilirubin concentrations (r
= 0.99). Plasma TEAC was compared before and after exchange transfusions for neonatal hyperbilirubinemia (250–435 μmol/l). The antioxidant properties of the paired blood samples before and after exchange transfusions (TEAC: 1.67 ± 0.12 vs. 1.37 ± 0.09 mmol/l, n = 11) varied in proportion to the serum bilirubin levels. The changes in other antioxidants were not large enough to account for the magnitude of change in antioxidant capacity. Therefore, in vivo, the plasma antioxidant capacity of jaundiced newborn infants is related to the level of bilirubin.
Philippe Chessex, MD, Research Center, Ste-Justine Hospital, 3175 Chemin Ste-Catherine, Montreal, Que H3T 1C5 (Canada), Tel.+1 514 345 4730, Fax+1 514 345 4801, E-Mail: email@example.com
Published online: October 01, 2009
Number of Print Pages : 6
Neonatology (Fetal and Neonatal Research)
Vol. 71, No. 4, Year 1997 (Cover Date: 1997)
Journal Editor: Halliday H.L. (Belfast), Speer C.P. (Würzburg)
ISSN: 1661-7800 (Print), eISSN: 1661-7819 (Online)
For additional information: http://www.karger.com/NEO
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