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Inactivation of Human Viruses by Povidone-Iodine in Comparison with Other AntisepticsKawana R.a · Kitamura T.b · Nakagomi O.c · Matsumoto I.d · Arita M.e · Yoshihara N.e · Yanagi K.e · Yamada A.e · Morita O.f · Yoshida Y.g · Furuya Y.g · Chiba S.h
aMorioka Yuuai General Hospital, Morioka (Professor Emeritus, Iwate Medical University), bToyama Institute of Health, Toyama (Director Emeritus, National Institute of Infectious Disease), cAkita University School of Medicine, Akita, dHoyo Hospital, Ishidoriya, Iwate, eNational Institute of Infectious Disease, Tokyo, fToyama Institute of Health, Toyama, gKanagawa Prefectural Public Health Laboratory, Yokohama, and hSapporo Medical College, Sapporo, Japan
Inactivation of a range of viruses, such as adeno-, mumps, rota-, polio- (types 1 and 3), coxsackie-, rhino-, herpes simplex, rubella, measles, influenza and human immunodeficiency viruses, by povidone-iodine (PVP-I) and other commercially available antiseptics in Japan was studied in accordance with the standardized protocol in vitro. In these experiments, antiseptics such as PVP-I solution, PVP-I gargle, PVP-I cream, chlorhexidine gluconate, alkyldiamino-ethyl-glycine hydrochloride, benzalkonium chloride (BAC) and benzethonium chloride (BEC) were used. PVP-I was effective against all the virus species tested. PVP-I drug products, which were examined in these experiments, inactivated all the viruses within a short period of time. Rubella, measles, mumps viruses and HIV were sensitive to all of the antiseptics, and rotavirus was inactivated by BAC and BEC, while adeno-, polio- and rhinoviruses did not respond to the other antiseptics. PVP-I had a wider virucidal spectrum, covering both enveloped and nonenveloped viruses, than the other commercially available antiseptics.
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