Journal Mobile Options
Table of Contents
Vol. 193, No. 2, 1996
Issue release date: 1996
Section title: Clinical and Laboratory Investigation
Dermatology 1996;193:94–99
(DOI:10.1159/000246220)

Urticarial Pathology in Schnitzler’s (Hyper-IgM) Syndrome

de Castroa F.R.a · Masouyé I.b · Winkelmann R.K.a · Saurat J.-H.b
aDepartment of Dermatology, Mayo Clinic Scottsdale, Scottsdale, Ariz., USA; bDepartment of Dermatology, University of Geneva, Geneva, Switzerland

Do you have an account?

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

Register and profit from personalized services (MyKarger) Login Information

Please create your User ID & Password





Contact Information









I have read the Karger Terms and Conditions and agree.

To view the fulltext, please log in

To view the pdf, please log in

Buy

  • FullText & PDF
  • Unlimited re-access via MyKarger (new!)
  • Unrestricted printing, no saving restrictions for personal use
  • Reduced rates with a PPV account
read more

Direct: USD 38.00
Account: USD 26.50

Select

Rent/Cloud

  • Rent for 48h to view
  • Buy Cloud Access for unlimited viewing via different devices
  • Synchronizing in the ReadCube Cloud
  • Printing and saving restrictions apply

Rental: USD 8.50
Cloud: USD 20.00

Select

Subscribe

  • Access to all articles of the subscribed year(s) guaranteed for 5 years
  • Unlimited re-access via Subscriber Login or MyKarger
  • Unrestricted printing, no saving restrictions for personal use
read more

Subcription rates


Select


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 5/16/1995
Accepted: 1/25/1996
Published online: 10/6/2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Schnitzler’s syndrome is a rare disorder characterized by chronic urticaria and monoclonal IgM gammopathy. The mechanisms of the urticarial flares remain poorly understood. Objective: To more accurately define the histopathologic changes in urticarial lesions, we reviewed 25 original biopsies from 15 cases of Schnitzler’s syndrome, 11 of which have previously been reported. Results: Thirteen specimens from 9 patients showed urticaria with neutrophils (neutrophilic urticaria). Necrotizing leukocytoclastic vasculitis with positive immunofluorescence studies was found only in 2 biopsies from 1 patient who was genetically deficient in C4. Five specimens showed lymphocytic urticaria. Four biopsies demonstrated a spongiotic dermatitis; an eosinophilic spongiosis was seen in 2 biopsies from a patient who later developed pemphigus vulgaris. Epidermal changes were seen in 17 specimens from 10 patients. Conclusions: The histopathologic findings in Schnitzler’s syndrome are not uniform although most cases demonstrated neutrophilic urticaria. Neutrophils in Schnitzler’s syndrome are not usually related to immune complex vasculitis. Epidermal changes in Schnitzler’s syndrome need to be further analyzed.

© 1996 S. Karger AG, Basel


  

Author Contacts

Prof. Dr. J.-H. Saurat, Department of Dermatology, University of Geneva, 24, rue Micheli-du-Crest, CH-1211 Geneva 14 (Switzerland)

  

Article Information

Received: May 16, 1995
Accepted: January 25, 1996
Published online: October 06, 2009
Number of Print Pages : 6

  

Publication Details

Dermatology

Vol. 193, No. 2, Year 1996 (Cover Date: 1996)

Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 5/16/1995
Accepted: 1/25/1996
Published online: 10/6/2009
Issue release date: 1996

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.