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Vol. 192, No. 4, 1996
Issue release date: 1996
Section title: Clinical and Laboratory Investigation
Dermatology 1996;192:307–311
(DOI:10.1159/000246400)

Decreased Bone Mineral Density in Patients with Pustulosis palmaris et plantaris

Nymann P.a · Kollerup G.b · Jemec G.B.E.a · Grossmann E.c
aDepartment of Dermatology, Bispebjerg Hospital, and bThe Osteoporosis Research Centre, Copenhagen Municipal Hospital, and cDepartment of Radiology, Sundby Hospital, Copenhagen, Denmark

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 9/19/1995
Accepted: 11/10/1995
Published online: 10/7/2009
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

Background: Focal skeletal changes in patients with pustulosis palmaris et plantaris (PPP) are known to occur in a minority of patients. It is unknown whether these changes are unique events or whether they merely represent more progressed cases. Objective: The study was undertaken in order to investigate possible diffuse bone changes in patients with PPP. Methods: Bone mineral density (BMD) and biochemical markers of bone turnover were studied in 18 female patients and 18 age-matched controls. Results: A significant correlation was found between lower-forearm BMD and disease duration (< 0.05). With increasing age, patients had significantly lower values than controls for both forearm and spine BMD (p < 0.005); patients who had PPP for more than 2 years had significantly reduced forearm BMD (19.8%; 95% CI: 5.6–32.8%)) and spine BMD (17.4%; 95% CI: 0.9–33.8%). No significant differences were observed in biochemical markers of bone turnover, physical activity or body mass index between patients and controls. The proportion of smokers among patients was four times higher than among controls (p < 0.0005). No significant dose effect was found between number of pack-years and BMD. Conclusion: Although we cannot exclude that prolonged use of topical steroids under occlusion is a confounding factor, the study suggests that PPP patients have decreased BMD due to primary pathogenic events, and that osteoporosis may be an additional problem for these patients.

© 1996 S. Karger AG, Basel


  

Author Contacts

G.B.E. Jemec, Strandvejen 97, III tv, DK-2900 Hellerup (Denmark)

  

Article Information

Received: September 19, 1995
Accepted: November 10, 1995
Published online: October 07, 2009
Number of Print Pages : 5

  

Publication Details

Dermatology

Vol. 192, No. 4, Year 1996 (Cover Date: 1996)

Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 9/19/1995
Accepted: 11/10/1995
Published online: 10/7/2009
Issue release date: 1996

Number of Print Pages: 5
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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