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Vol. 188, No. 2, 1994
Issue release date: 1994
Section title: Clinical and Laboratory Investigation
Dermatology 1994;188:94–99
(DOI:10.1159/000247109)

DNA Flow-Cytometric Analysis of Basal Cell Carcinomas and Its Relevance to Their Morphological Differentiation: A Retrospective Study

Fortier-Beaulieu M.a · Laquerrière A.b · Thomine E.b · Lauret P.a · Hémet J.b
aClinique Dermatologique et bLaboratoire d’Anatomie Pathologique, Centre Hospitalier Regional et Universitaire, Rouen, France

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 9/7/1992
Accepted: 5/7/1993
Published online: 10/7/2009
Issue release date: 1994

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

DNA flow cytometry (FCM) was performed on archived material of 82 basal cell carcinomas (BCC), using Hedley’s technique. Sixty-five samples were analysed. Biopsy samples were classified in five groups depending on their morphological differentiation: solid, cystic, adenoid, keratotic andmetatypical. Two parameters were studied: proliferative index and DNA index. Statistical analysis revealed that BCC with keratinizing or metatypical differentiation had a greater amount of aneuploidy when compared with BCC without particular differentiation (solid and cystic) or aneuploid differentiation (p < 0.001). The proliferative indices were significantly different in the four groups. DNA FCM of BCC confirms the value of morphological classifications and gives another example of aneuploidy in a tumour with low aggressiveness.

© 1994 S. Karger AG, Basel


  

Author Contacts

Marc Fortier-Beaulieu, Clinique Dermatologique, CHU de Rouen, 1, rue de Germont, F-76031 Rouen Cedex (France)

  

Article Information

Received: September 7, 1992
Accepted: May 7, 1993
Published online: October 07, 2009
Number of Print Pages : 6

  

Publication Details

Dermatology

Vol. 188, No. 2, Year 1994 (Cover Date: 1994)

Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 9/7/1992
Accepted: 5/7/1993
Published online: 10/7/2009
Issue release date: 1994

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
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