Pharmacology and Treatment
L-Phenylalanine and UVA Irradiation in the Treatment of VitiligoSiddiqui A.H.a · Stolk L·M.L.b · Bhaggoe R.a · Hu R.a · Schutgens R.B.H.c · Westerhof W.a
Departments of aDermatology, bPharmacy and cPediatrics, Academisch Medisch Centrum, University of Amsterdam, The Netherlands
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Article / Publication Details
In order to evaluate the efficacy of L-phenylalanine (L-Phe) in combination with UVA therapy for vitiligo an open trial (149 patients, 18 months) and a small double-blind trial (32 patients, 6 months) were conducted. Oral L-Phe loading resulted in peak plasma levels of L-Phe after 30–60 min and a slight increase in the plasma tyrosine level. Response to L-Phe plus UVA irradiation was positive, and various grades of repigmentation not exceeding 77% in the open and 60% in the blind trial were observed. An increased L-Phe dose resulted in increased L-Phe plasma levels but not in improved clinical results. The optimal L-Phe dose appears to be lower than 50 mg/kg/day. Although it is difficult to draw firm conclusions from the present investigation, we think that L-Phe may have a place in the treatment of vitiligo and its role merits further investigation.
© 1994 S. Karger AG, Basel
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