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Vol. 184, No. 1, 1992
Issue release date: 1992
Section title: Clinical and Laboratory Investigation
Dermatology 1992;184:2–7
(DOI:10.1159/000247489)

Comparison of Nonfamilial and Familial Melanoma

Barnhill R.L.a · Roush G.C.b · Titus-Ernstoff L.c · Ernstoff M.S.c · Duray P.H.d · Kirkwood J.M.c
aDermatopathology Division, Harvard Medical School, General Hospital, Boston, Mass.; bCancer Prevention Research Institute, New York, N.Y.; cDepartments of Epidemiology and Medicine (Medical Oncology), University of Pittsburgh, Pa.; dFox Chase Cancer Center, Philadelphia, Pa., USA

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Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 3/21/1991
Accepted: 6/6/1991
Published online: 10/8/2009
Issue release date: 1992

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM

Abstract

There has been concern that individuals with nonfamilial melanoma and dysplastic melanocytic nevi (DMN) are not directly comparable to patients with hereditary melanoma and DMN. Because we have conducted a comprehensive study of nonfamilial melanoma over the past several years, we have addressed the above issue by directly comparing the characteristics of 145 nonfamilial patients, 6 patients with familial melanoma and the information available for familial melanoma in the literature. All 6 patients with familial melanoma had at least one first-degree blood relative with cutaneous melanoma. A large number of clinical and histologic variables were compared for both groups. Some pertinent variables included mean age at melanoma diagnosis 46.7 versus 52.3 years, mean Breslow thickness 2.11 versus 1.54 mm, mean total body nevi per patient 20.6 versus 18.3, mean total clinically atypical nevi per patient 2.0 versus 1.7 and total histologically confirmed DMN per group 22 (18.3%) versus 2 (33%), for patients with nonfamilial versus familial melanoma, respectively. No substantial differences were observed between the two groups. A review of the medical literature failed to reveal any quantitative data for melanocytic nevi, either clinical or histologic, at present that would allow distinction of patients with sporadic versus familial melanoma. We conclude that studies concerning the clinical characteristics of patients with DMN and nonfamilial melanoma are relevant to other persons with DMN including familial melanoma.

© 1992 S. Karger AG, Basel


  

Author Contacts

Raymond L. Barnhill, MD, Division of Dermatopathology, Massachusetts General Hospital, Warren Bldg., Room 827, Boston, MA 02114 (USA)

  

Article Information

Received: March 21, 1991
Accepted: June 6, 1991
Published online: October 08, 2009
Number of Print Pages : 6

  

Publication Details

Dermatology

Vol. 184, No. 1, Year 1992 (Cover Date: 1992)

Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


Article / Publication Details

First-Page Preview
Abstract of Clinical and Laboratory Investigation

Received: 3/21/1991
Accepted: 6/6/1991
Published online: 10/8/2009
Issue release date: 1992

Number of Print Pages: 6
Number of Figures: 0
Number of Tables: 0

ISSN: 1018-8665 (Print)
eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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