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Table of Contents
Vol. 43, No. 2, 2010
Issue release date: January 2010
Section title: Original Paper
Ophthalmic Res 2010;43:92–98
(DOI:10.1159/000247593)

Combined Three-Dimensional Spectral OCT/SLO Topography and Microperimetry: Steps toward Achieving Functional Spectral OCT/SLO

Landa G.a, c · Rosen R.B.a, c · Garcia P.M.T.a, c · Seiple W.H.a, b
aDepartment of Ophthalmology, Retina Center, New York Eye and Ear Infirmary, and bLighthouse International, New York, N.Y., cDepartment of Ophthalmology, New York Medical College, Valhalla, N.Y., USA

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 06, 2009
Accepted: June 08, 2009
Published online: October 15, 2009
Issue release date: January 2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: http://www.karger.com/ORE

Abstract

Aims: To investigate the combination of 3D optical coherence tomography (OCT) retinal thickness measurements and superimposed scanning laser ophthalmoscopy (SLO) microperimetry obtained using a Spectral OCT/SLO and to test the correlation between retinal thickness and retinal sensitivity in retinal diseases grouped according to anatomic locations. Methods: Patients with various retinal diseases and subjects with normal fundi underwent microperimetry testing and imaging with the Spectral OCT/SLO. Based on the Spectral OCT/SLO findings, the participants were divided into 4 groups: patients with retinal thickening due to the outer retina pathology (group I); patients with retinal thickening due to the cystic changes observed in the inner retina (group II); patients with macular neurosensory retina thinning associated with geographic atrophy or underlying subretinal cicatricial changes (group III), and subjects with unremarkable fundus appearance and normal appearing retina on Spectral OCT/SLO (group IV). The primary outcome was the correlation coefficient (r) between Spectral OCT/SLO-measured macular thickness and microperimetry values. Results: Correlations between retinal thickness and psychophysical thresholds were calculated for each patient, and these values were averaged within groups. The mean correlation values (Pearson product movement) were as follows: for group I (n = 21 eyes) r = 0.04; for group II (n = 24 eyes) r = –0.53; for group III (n = 16 eyes) r = 0.41, and for group IV (n = 15 eyes) r = 0.04. Conclusions: The combination of 3D OCT images and superimposed SLO microperimetry obtained by Spectral OCT/SLO demonstrated that thickening due to cystic changes of the inner retinal layers or thinning of the neurosensory retina on OCT correlated most significantly with decreases in psychophysical threshold sensitivities.

© 2009 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Received: March 06, 2009
Accepted: June 08, 2009
Published online: October 15, 2009
Issue release date: January 2010

Number of Print Pages: 7
Number of Figures: 3
Number of Tables: 0

ISSN: 0030-3747 (Print)
eISSN: 1423-0259 (Online)

For additional information: http://www.karger.com/ORE


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