A Prospective Study on Mother-to-Infant Transmission of Hepatitis C VirusZanetti A.R. · Tanzi E. · Romanò L. · Zuin G. · Minola E. · Vecchi L. · Principi N.
a Institute of Virology, and b Pediatrics Department IV, University of Milan, c Infectious Diseases Division, ‘Ospedali Riuniti’, Bergamo, d Biochemical Chemistry Department, ‘Ospedale S. Gerardo’, Monza, Italy
To assess the rate of mother-to-infant transmission of hepatitis C virus (HCV) and to identify potential risk factors for transmission, we followed up (mean 22.4 months, range 1–7.5 years) a cohort of 291 babies born to anti-HCV-positive mothers, 40 of whom were also HIV coinfected. Seventeen (5.8%) babies acquired HCV infection, but none became icteric. All babies developed chronic HCV infection with 16 babies showing elevated levels of ALT. The rate of transmission was higher in babies born to mothers coinfected with HIV than in those born to mothers with HCV alone (22.5 vs. 3.2%, p < 0.0001). No association was seen between a specific maternal HCV genotype and an increased risk of neonatal infection. The median level of HCV-RNA was higher in mothers who transmitted infection than in those who did not, although the ranges overlapped. In this study, maternal history of chronic liver disease, mode of delivery and type of feeding were not predictive of HCV infection.
Prof. A.R. Zanetti
Institute of Virology, University of Milan
Via Pascal 38
I–20133 Milan (Italy)
Tel. +39 02 266 3946, Fax +39 02 266 80713, E-Mail firstname.lastname@example.org
Number of Print Pages : 5
Number of Figures : 4, Number of Tables : 3, Number of References : 22
Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)
Vol. 41, No. 4-5, Year 1998 (Cover Date: July-October 1998 (Released April 1999))
Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)
For additional information: http://www.karger.com/journals/int