Chronic Deep Brain Stimulation for Segmental DystoniaWoehrle J.C. · Blahak C. · Kekelia K. · Capelle H.-H. · Baezner H. · Grips E. · Weigel R. · Krauss J.K.
Departments of aNeurology and bNeurosurgery, Universitätsklinikum Mannheim, Mannheim, cDepartment of Neurosurgery, Medical School Hannover, MHH, Hannover, and dDepartment of Neurology, Katholisches Klinikum, Koblenz, Germany
Fourteen consecutive patients with segmental dystonia underwent chronic deep brain stimulation (DBS) surgery in the frame of a prospective study protocol. Twelve patients received chronic pallidal stimulation, while 2 patients with prominent dystonic tremor received chronic thalamic ventrointermediate nucleus stimulation. Twelve patients had primary dystonia, and 2 patients secondary dystonia. The Burke-Fahn-Marsden dystonia rating scale (BFM motor) showed a mean relative improvement of 57.3% at the first follow-up (FU1, mean 7 months) and 57.8% at the second follow-up (FU2, mean 16 months). The mean BFM scores were 34.9 ± 17.7 preoperatively, 14.9 ± 11.7 at FU1, and 14.8 ± 10.3 at FU2. Scores of the disability subscale improved by 43% at FU1 and 36% at FU2. Improvement was comparatively less in those patients with secondary dystonia. Dysarthria was a limitation of DBS in 4 patients when using high voltage. Overall, chronic DBS is a very effective treatment option for medically refractory segmental dystonia.
Prof. Dr. med. J.K. Krauss
Department of Neurosurgery, Medical School Hannover, MHH
Carl Neuberg Strasse 1
DE–30652 Hannover (Germany)
Tel. +49 511 532 6650, Fax +49 511 532 5864, E-Mail email@example.com
J.K.K. is a consultant to Medtronic. H.-H.C. has received speaker’s honoraria from Medtronic.
Received: April 23, 2009
Accepted after revision: July 28, 2009
Published online: October 21, 2009
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 1, Number of References : 19
Stereotactic and Functional Neurosurgery
Vol. 87, No. 6, Year 2009 (Cover Date: November 2009)
Journal Editor: Roberts D.W. (Lebanon, N.H.)
ISSN: 1011-6125 (Print), eISSN: 1423-0372 (Online)
For additional information: http://www.karger.com/SFN