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Vol. 87, No. 6, 2009
Issue release date: November 2009
Section title: Clinical Study
Stereotact Funct Neurosurg 2009;87:379–384
(DOI:10.1159/000249819)

Chronic Deep Brain Stimulation for Segmental Dystonia

Woehrle J.C. · Blahak C. · Kekelia K. · Capelle H.-H. · Baezner H. · Grips E. · Weigel R. · Krauss J.K.
Departments of aNeurology and bNeurosurgery, Universitätsklinikum Mannheim, Mannheim, cDepartment of Neurosurgery, Medical School Hannover, MHH, Hannover, and dDepartment of Neurology, Katholisches Klinikum, Koblenz, Germany

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Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/23/2009
Accepted: 7/28/2009
Published online: 10/21/2009

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN

Abstract

Fourteen consecutive patients with segmental dystonia underwent chronic deep brain stimulation (DBS) surgery in the frame of a prospective study protocol. Twelve patients received chronic pallidal stimulation, while 2 patients with prominent dystonic tremor received chronic thalamic ventrointermediate nucleus stimulation. Twelve patients had primary dystonia, and 2 patients secondary dystonia. The Burke-Fahn-Marsden dystonia rating scale (BFM motor) showed a mean relative improvement of 57.3% at the first follow-up (FU1, mean 7 months) and 57.8% at the second follow-up (FU2, mean 16 months). The mean BFM scores were 34.9 ± 17.7 preoperatively, 14.9 ± 11.7 at FU1, and 14.8 ± 10.3 at FU2. Scores of the disability subscale improved by 43% at FU1 and 36% at FU2. Improvement was comparatively less in those patients with secondary dystonia. Dysarthria was a limitation of DBS in 4 patients when using high voltage. Overall, chronic DBS is a very effective treatment option for medically refractory segmental dystonia.


  

Author Contacts

Prof. Dr. med. J.K. Krauss
Department of Neurosurgery, Medical School Hannover, MHH
Carl Neuberg Strasse 1
DE–30652 Hannover (Germany)
Tel. +49 511 532 6650, Fax +49 511 532 5864, E-Mail krauss.joachim@mh-hannover.de

  

Article Information

J.K.K. is a consultant to Medtronic. H.-H.C. has received speaker’s honoraria from Medtronic.

Received: April 23, 2009
Accepted after revision: July 28, 2009
Published online: October 21, 2009
Number of Print Pages : 6
Number of Figures : 1, Number of Tables : 1, Number of References : 19

  

Publication Details

Stereotactic and Functional Neurosurgery

Vol. 87, No. 6, Year 2009 (Cover Date: November 2009)

Journal Editor: Roberts D.W. (Lebanon, N.H.)
ISSN: 1011-6125 (Print), eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


Article / Publication Details

First-Page Preview
Abstract of Clinical Study

Received: 4/23/2009
Accepted: 7/28/2009
Published online: 10/21/2009

Number of Print Pages: 6
Number of Figures: 1
Number of Tables: 1

ISSN: 1011-6125 (Print)
eISSN: 1423-0372 (Online)

For additional information: http://www.karger.com/SFN


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