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Table of Contents
Vol. 43, No. 2, 2000
Issue release date: August 2000
Section title: Short Communication
Intervirology 2000;43:124–127
(DOI:10.1159/000025035)

Identification of a Single Nucleotide Polymorphism in the MxA Gene Promoter (G/T at nt –88) Correlated with the Response of Hepatitis C Patients to Interferon

Hijikata M.a · Ohta Y.b · Mishiro S.a
Departments of aMedical Sciences, and bGastroenterology, Toshiba General Hospital, Shinagawa-ku, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Short Communication

Published online: August 28, 2000
Issue release date: August 2000

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

The interferon (IFN)-inducible MxA protein is known to play an important role in the host defense against certain viruses. We aimed to see if any genetic polymorphism in the promoter region of the MxA gene is associated with the IFN responsiveness of hepatitis C virus (HCV)-infected patients. Initially we sequenced the promoter region of the MxA gene in 12 subjects and found a polymorphic site. We then constructed a specific PCR-RFLP system for this site and subjected 63 samples from chronic hepatitis C patients who were nonresponders (NR) to IFN therapy to it, 52 with sustained response (SR), and 42 healthy controls. Subjects were all Japanese, and unrelated. A single nucleotide polymorphism (SNP) was identified in the MxA promoter region: G/T alleles at nt position –88. Interestingly, this SNP was involved in a genetic element highly homologous to the IFN-stimulated response element consensus sequence, and the G-to-T change there makes this homology a little greater. The rate of G·G homozygosity was 31% in the SR patients, significantly lower than in the NR patients (62%, p = 0.0009), while that of healthy controls was between the two groups (48%). Differences in HCV genotypes did not influence this result. Based on these findings, we propose that the SNP of the MxA promoter at nt –88 identified in this study affects the expression of MxA protein, and may thus be associated with the response of HCV patients to IFN.

© 2000 S. Karger AG, Basel


Article / Publication Details

First-Page Preview
Abstract of Short Communication

Published online: August 28, 2000
Issue release date: August 2000

Number of Print Pages: 4
Number of Figures: 1
Number of Tables: 2

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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