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Vol. 43, No. 3, 2000
Issue release date: May–June 2000 (October 2000)
Section title: Original Paper
Intervirology 2000;43:174–179
(DOI:10.1159/000025043)

Relationship between Five-Year Histological Outcome and Serial Changes in Serum Alanine Aminotransferase in Patients with Biochemical and Virological Relapse after Interferon Treatment for Chronic Hepatitis C

Kobayashi M. · Ikeda K. · Akuta N. · Someya T. · Suzuki F. · Tsubota A. · Suzuki Y. · Saitoh S. · Arase Y. · Chayama K. · Kumada H.
Department of Gastroenterology, Toranomon Hospital, Minato-ku, Tokyo, Japan

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Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 10/23/2000

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT

Abstract

Objective: The aim of this study was to assess the correlation between serial changes in serum alanine aminotransferase (ALT) levels and histological outcome 5 years after treatment of patients with chronic hepatitis C with interferon (IFN). Methods: We retrospectively evaluated 61 consecutive patients who underwent two liver biopsies, just before and 5 years after a 6-month course of IFN therapy, and who showed a relapse after therapy. The extent of liver fibrosis was estimated using a scale with seven grades. Results: At the end of 6-month IFN therapy, 40 (65.6%) patients had normal serum ALT concentrations. However, 13 of the 40 patients relapsed within 6 months after IFN therapy. The average ALT during 5 years in 40 patients was less than or equal to 75 IU/l, while in the other 21 patients it was more than 75 IU/l. Among the 40 patients with a mean ALT less than 75 IU/l, 13 (33%) patients showed histological improvement, 26 (65%) showed no changes and only 1 patient (2%) showed worsening of liver fibrosis. On the other hand, among the 21 patients with a mean ALT of more than 75 IU/l, only 1 (5%) patient showed improvement, 8 (38%) showed no changes and 12 patients (57%) showed worsening of liver fibrosis. Conclusion: There is a significant relationship between 5-year histological outcome and serial changes in serum ALT in patients with biochemical and virological relapse after IFN treatment for chronic hepatitis C.


  

Author Contacts

Masahiro Kobayashi, MD
Department of Gastroenterology, Toranomon Hospital
2-2-2 Toranomon, Minato-ku, 105-8470 Tokyo (Japan)
Tel. +81 44 877 5111, Fax +81 44 860 1623
E-Mail mshkoba@d8.dion.ne.jp

  

Article Information

Received: Received: June 26, 2000
Accepted: July 10, 2000
Number of Print Pages : 6
Number of Figures : 4, Number of Tables : 1, Number of References : 24

  

Publication Details

Intervirology (International Journal of Basic and Medical Virology)
Founded 1973 by J.L. Melnick; continued by F. Rapp (1986–1990); M.J. Buchmeier and C.R. Howard (1991–1993)

Vol. 43, No. 3, Year 2000 (Cover Date: May-June 2000 (Released October 2000))

Journal Editor: Rüdiger W. Braun, Stuttgart
ISSN: 0300–5526 (print), 1423–0100 (Online)

For additional information: http://www.karger.com/journals/int


Article / Publication Details

First-Page Preview
Abstract of Original Paper

Published online: 10/23/2000

Number of Print Pages: 6
Number of Figures: 4
Number of Tables: 1

ISSN: 0300-5526 (Print)
eISSN: 1423-0100 (Online)

For additional information: http://www.karger.com/INT


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