Journal Mobile Options
Table of Contents
Vol. 157, No. 4, 1978
Issue release date: 1978
Dermatologica 1978;157:245–253
Original Paper

A Clinical and Bacteriological Evaluation of the Effect of Sulphamethoxazole-Trimethoprim in Acne vulgaris, Resistant to Prior Therapy with Tetracyclines

Nordin K. · Hallander H. · Fredriksson T. · Rylander C.
Departments of Dermatology and Clinical Bacteriology, Central Hospital, Västerås, and Department of Clinical Research, Roche-Produkter AB, Skärholmen


42 patients with acne vulgaris, clinically resistant to prior therapy with tetracyclines, were evaluated after therapy with sulphamethoxazole-trimethoprim (400 + 80 mg) twice daily. Initially and after 6, 12 and 18 weeks of treatment in each patient the different acne lesions were counted and pus specimens from unhealed pustules were taken for bacteriological analysis. Complete remission or excellent results were obtained in 33 patients (79%) at the end of treatment despite a relative increase of Staphylococcus hominis and Propionibacterium granulosum. These species were more resistant in agar dilution test to the combination sulphamethoxazole-trimethoprim (20:1) than other isolated species.

 goto top of outline Author Contacts

Dr. Karin Nordin, Department of Dermatology, Central Hospital, S-721 89 Västerås (Sweden)

 goto top of outline Article Information

Received: September 19, 1977
Accepted: January 13, 1978
Published online: October 14, 2009
Number of Print Pages : 9

 goto top of outline Publication Details


Vol. 157, No. 4, Year 1978 (Cover Date: 1978)

Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)

For additional information:

Copyright / Drug Dosage

Copyright: All rights reserved. No part of this publication may be translated into other languages, reproduced or utilized in any form or by any means, electronic or mechanical, including photocopying, recording, microcopying, or by any information storage and retrieval system, without permission in writing from the publisher or, in the case of photocopying, direct payment of a specified fee to the Copyright Clearance Center.
Drug Dosage: The authors and the publisher have exerted every effort to ensure that drug selection and dosage set forth in this text are in accord with current recommendations and practice at the time of publication. However, in view of ongoing research, changes in goverment regulations, and the constant flow of information relating to drug therapy and drug reactions, the reader is urged to check the package insert for each drug for any changes in indications and dosage and for added warnings and precautions. This is particularly important when the recommended agent is a new and/or infrequently employed drug.
Disclaimer: The statements, opinions and data contained in this publication are solely those of the individual authors and contributors and not of the publishers and the editor(s). The appearance of advertisements or/and product references in the publication is not a warranty, endorsement, or approval of the products or services advertised or of their effectiveness, quality or safety. The publisher and the editor(s) disclaim responsibility for any injury to persons or property resulting from any ideas, methods, instructions or products referred to in the content or advertisements.