42 patients with acne vulgaris, clinically resistant to prior therapy with tetracyclines, were evaluated after therapy with sulphamethoxazole-trimethoprim (400 + 80 mg) twice daily. Initially and after 6, 12 and 18 weeks of treatment in each patient the different acne lesions were counted and pus specimens from unhealed pustules were taken for bacteriological analysis. Complete remission or excellent results were obtained in 33 patients (79%) at the end of treatment despite a relative increase of Staphylococcus hominis
and Propionibacterium granulosum.
These species were more resistant in agar dilution test to the combination sulphamethoxazole-trimethoprim (20:1) than other isolated species.
Dr. Karin Nordin, Department of Dermatology, Central Hospital, S-721 89 Västerås (Sweden)
Received: September 19, 1977
Accepted: January 13, 1978
Published online: October 14, 2009
Number of Print Pages : 9
Vol. 157, No. 4, Year 1978 (Cover Date: 1978)
Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)
For additional information: http://www.karger.com/DRM
Copyright / Drug Dosage
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