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Vol. 157, No. 4, 1978
Issue release date: 1978
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Dermatologica 1978;157:245–253
(DOI:10.1159/000250840)
Original Paper

A Clinical and Bacteriological Evaluation of the Effect of Sulphamethoxazole-Trimethoprim in Acne vulgaris, Resistant to Prior Therapy with Tetracyclines

Nordin K. · Hallander H. · Fredriksson T. · Rylander C.
Departments of Dermatology and Clinical Bacteriology, Central Hospital, Västerås, and Department of Clinical Research, Roche-Produkter AB, Skärholmen Dermatologica 1978;157:245–253 (DOI:10.1159/000250840)

Abstract

42 patients with acne vulgaris, clinically resistant to prior therapy with tetracyclines, were evaluated after therapy with sulphamethoxazole-trimethoprim (400 + 80 mg) twice daily. Initially and after 6, 12 and 18 weeks of treatment in each patient the different acne lesions were counted and pus specimens from unhealed pustules were taken for bacteriological analysis. Complete remission or excellent results were obtained in 33 patients (79%) at the end of treatment despite a relative increase of Staphylococcus hominis and Propionibacterium granulosum. These species were more resistant in agar dilution test to the combination sulphamethoxazole-trimethoprim (20:1) than other isolated species.

 goto top of outline Author Contacts

Dr. Karin Nordin, Department of Dermatology, Central Hospital, S-721 89 Västerås (Sweden)


 goto top of outline Article Information

Received: September 19, 1977
Accepted: January 13, 1978
Published online: October 14, 2009
Number of Print Pages : 9


 goto top of outline Publication Details

Dermatology

Vol. 157, No. 4, Year 1978 (Cover Date: 1978)

Journal Editor: Saurat J.-H. (Geneva)
ISSN: 1018-8665 (Print), eISSN: 1421-9832 (Online)

For additional information: http://www.karger.com/DRM


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